Reveromycin A
Reveromycin A structure
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Common Name | Reveromycin A | ||
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| CAS Number | 134615-37-5 | Molecular Weight | 660.79100 | |
| Density | 1.21g/cm3 | Boiling Point | 849ºC at 760mmHg | |
| Molecular Formula | C36H52O11 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 258.7ºC | |
Use of Reveromycin AReveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity[1][2]. |
| Name | Reveromycin A |
|---|---|
| Synonym | More Synonyms |
| Description | Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity[1][2]. |
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| Related Catalog | |
| In Vitro | Reveromycin A inhibits protein synthesis in osteoclasts (OCs) by selectively blocking enzymatic activity of isoleucyl-tRNA synthetase[2]. Reveromycin A (0.3-30 μM; for 24 h) induces apoptosis in OCs through inhibition of protein synthesis[2]. |
| In Vivo | Reveromycin A (20 mg/kg; twice daily; i.v.; for 3 days) significantly decreases numbers of OCs without affecting numbers of osteoblasts in normal 4-week-old male Sprague-Dawley rats[2]. |
| References |
| Density | 1.21g/cm3 |
|---|---|
| Boiling Point | 849ºC at 760mmHg |
| Molecular Formula | C36H52O11 |
| Molecular Weight | 660.79100 |
| Flash Point | 258.7ºC |
| Exact Mass | 660.35100 |
| PSA | 176.89000 |
| LogP | 6.13130 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.561 |
| InChIKey | ZESGNAJSBDILTB-JJKMAANASA-N |
| SMILES | CCCCC1(OC(=O)CCC(=O)O)CCC2(CCC(C)C(CC=C(C)C=CC(O)C(C)C=CC(=O)O)O2)OC1C=CC(C)=CC(=O)O |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
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Development and application of bioprobes for Mammalian cell cycle analyses.
Curr. Med. Chem. 10(9) , 727-32, (2003) In this review, I have mainly described the cell cycle inhibitors isolated from microbial metabolites. Once the molecular target of the inhibitor is determined, the inhibitor can be used as bioprobe t... |
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Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases.
Cancer Sci. 100(11) , 1999-2005, (2009) Osteoclasts are highly specialized cells that resorb bone, and their abnormal activity is implicated in a variety of human bone diseases. In neoplastic bone metastasis, the bone destruction caused by ... |
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Synthesis and biological activities of reveromycin A and spirofungin A derivatives.
Bioorg. Med. Chem. Lett. 18(13) , 3756-60, (2008) Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory eff... |
| reveromycin a |