Reveromycin A

Names

[ Name ]:
Reveromycin A

[Synonym ]:
reveromycin a

Biological Activity

[Description]:

Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Reveromycin A inhibits protein synthesis in osteoclasts (OCs) by selectively blocking enzymatic activity of isoleucyl-tRNA synthetase[2]. Reveromycin A (0.3-30 μM; for 24 h) induces apoptosis in OCs through inhibition of protein synthesis[2].

[In Vivo]

Reveromycin A (20 mg/kg; twice daily; i.v.; for 3 days) significantly decreases numbers of OCs without affecting numbers of osteoblasts in normal 4-week-old male Sprague-Dawley rats[2].

[References]

[1]. H Takahashi , et al. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. J Antibiot (Tokyo). 1992 Sep;45(9):1414-9.

[2]. Je-Tae Woo, et al. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4729-34.

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
849ºC at 760mmHg

[ Molecular Formula ]:
C₃₆H₅₂O₁₁

[ Molecular Weight ]:
660.79100

[ Flash Point ]:
258.7ºC

[ Exact Mass ]:
660.35100

[ PSA ]:
176.89000

[ LogP ]:
6.13130

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.561

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

Development and application of bioprobes for Mammalian cell cycle analyses.

Curr. Med. Chem. 10(9) , 727-32, (2003)

In this review, I have mainly described the cell cycle inhibitors isolated from microbial metabolites. Once the molecular target of the inhibitor is determined, the inhibitor can be used as bioprobe t...

Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases.

Cancer Sci. 100(11) , 1999-2005, (2009)

Osteoclasts are highly specialized cells that resorb bone, and their abnormal activity is implicated in a variety of human bone diseases. In neoplastic bone metastasis, the bone destruction caused by ...

Synthesis and biological activities of reveromycin A and spirofungin A derivatives.

Bioorg. Med. Chem. Lett. 18(13) , 3756-60, (2008)

Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory eff...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.