FM1-43
FM1-43 structure
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Common Name | FM1-43 | ||
|---|---|---|---|---|
| CAS Number | 149838-22-2 | Molecular Weight | 611.53800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H49Br2N3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Regulation of density of functional presynaptic terminals by local energy supply.
Mol. Brain 8 , 42, (2015) The density of functional synapses is an important parameter in determining the efficacy of synaptic transmission. However, how functional presynaptic terminal density is regulated under natural physiological conditions is still poorly understood.We studied t... |
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A genomic region encompassing a newly identified exon provides enhancing activity sufficient for normal myo7aa expression in zebrafish sensory hair cells.
Dev. Neurobiol. 75 , 961-83, (2015) MYO7A is an unconventional myosin involved in the structural organization of hair bundles at the apex of sensory hair cells (SHCs) where it serves mechanotransduction in the process of hearing and balance. Mutations of MYO7A are responsible for abnormal shapi... |
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A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth.
Neuropharmacology 92 , 146-57, (2015) Alzheimer's disease is a neurodegenerative disorder characterized by deposition of β-amyloid (Aβ) fibrils accompanied with progressive neurite loss. None of the clinically approved anti-Alzheimer's agents target both pathological processes. We hypothesized th... |
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Drosophila S6 Kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor thickveins.
PLoS Genet. 11(3) , e1004984, (2015) Synaptic connections must be precisely controlled to ensure proper neural circuit formation. In Drosophila melanogaster, bone morphogenetic protein (BMP) promotes growth of the neuromuscular junction (NMJ) by binding and activating the BMP ligand receptors wi... |
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RFX transcription factors are essential for hearing in mice.
Nat. Commun. 6 , 8549, (2015) Sensorineural hearing loss is a common and currently irreversible disorder, because mammalian hair cells (HCs) do not regenerate and current stem cell and gene delivery protocols result only in immature HC-like cells. Importantly, although the transcriptional... |
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Simple perfusion apparatus for manipulation, tracking, and study of oocytes and embryos.
Fertil. Steril. 103(1) , 281-90.e5, (2015) To develop and implement a device and protocol for oocyte analysis at a single cell level. The device must be capable of high resolution imaging, temperature control, perfusion of media, drugs, sperm, and immunolabeling reagents all at defined flow rates. Eac... |
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Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration.
J. Cell Biol. 207(4) , 453-62, (2014) Synaptic demise and accumulation of dysfunctional proteins are thought of as common features in neurodegeneration. However, the mechanisms by which synaptic proteins turn over remain elusive. In this paper, we study Drosophila melanogaster lacking active TBC1... |
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The regulation of synaptic vesicle recycling by cGMP-dependent protein kinase type II in cerebellar granule cells under strong and sustained stimulation.
J. Neurosci. 34(26) , 8788-99, (2014) From the early periods of neurogenesis and migration, up until synaptogenesis, both nitric oxide (NO) and its downstream messenger, cGMP, are thought to influence the development of neurons. The NO/cGMP/cGMP-dependent protein kinase (cGK) pathway regulates th... |
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Presynaptic mechanisms of lead neurotoxicity: effects on vesicular release, vesicle clustering and mitochondria number.
PLoS ONE 10 , e0127461, (2015) Childhood lead (Pb2+) intoxication is a global public health problem and accounts for 0.6% of the global burden of disease associated with intellectual disabilities. Despite the recognition that childhood Pb2+ intoxication contributes significantly to intelle... |
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Dynamic properties of the alkaline vesicle population at hippocampal synapses.
PLoS ONE 9(7) , e102723, (2014) In compensatory endocytosis, scission of vesicles from the plasma membrane to the cytoplasm is a prerequisite for intravesicular reacidification and accumulation of neurotransmitter molecules. Here, we provide time-resolved measurements of the dynamics of the... |