2'-Deoxyadenosine-5'-triphosphate
2'-Deoxyadenosine-5'-triphosphate structure
|
Common Name | 2'-Deoxyadenosine-5'-triphosphate | ||
|---|---|---|---|---|
| CAS Number | 1927-31-7 | Molecular Weight | 535.145 | |
| Density | 2.5±0.1 g/cm3 | Boiling Point | 913.3±75.0 °C at 760 mmHg | |
| Molecular Formula | C10H14N5Na2O12P3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 506.1±37.1 °C | |
|
Crystal structures of a type-1 ribosome inactivating protein from Momordica balsamina in the bound and unbound states.
Biochim. Biophys. Acta 1824(4) , 679-91, (2012) The ribosome inactivating proteins (RIPs) of type 1 are plant toxins that eliminate adenine base selectively from the single stranded loop of rRNA. We report six crystal structures, type 1 RIP from Momordica balsamina (A), three in complexed states with ribos... |
|
|
Mechanism and fidelity of HIV reverse transcriptase.
J. Biol. Chem. 267 , 25988-25997, (1992) We have examined the RNA-dependent and DNA-dependent polymerase and ribonuclease H catalytic activities of human immunodeficiency virus reverse transcriptase using rapid transient kinetic methods with defined synthetic 25/45-mer DNA/RNA and DNA/DNA primer/tem... |
|
|
Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation.
Biochemistry 31 , 4473-4479, (1992) Steady-state and pre-steady-state kinetic constants were determined for reverse transcriptase catalyzed incorporation of nucleotides and nucleotide analogues into defined-sequence DNA primed-RNA templates. 3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) wa... |
|
|
Role of the 2-amino group of purines during dNTP polymerization by human DNA polymerase alpha.
Biochemistry 48 , 180-189, (2009) We used a series of dNTP analogues in conjunction with templates containing modified bases to elucidate the role that N(2) of a purine plays during dNTP polymerization by human DNA polymerase alpha. Removing N(2) from dGTP had small effects during correct inc... |
|
|
Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.
Biochemistry 48 , 4633-4641, (2009) We used a series of dATP and dGTP analogues to determine how DNA polymerase I from Bacillus stearothermophilus (BF), a prototypical A family polymerase, uses N-1, N(2), N-3, and N(6) of purine dNTPs to differentiate between right and wrong nucleotide incorpor... |
|
|
Reverse transcription of the ribonucleic acid: the first step in RT-PCR assay.
Methods Mol. Biol. 630 , 261-270, (2010) Reverse transcription (RT) is the synthesis of complementary deoxyribonucleic acids (DNA) from single-stranded ribonucleic acid (RNA) templates. This process is catalyzed by the reverse transcriptase enzyme, which is the replicating enzyme of retroviruses. Re... |
|
|
Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease.
FASEB J. 27(5) , 2013-26, (2013) Chronic obstructive pulmonary disease (COPD) is characterized by persistent inflammation and tissue remodeling and is a leading cause of death in the United States. Increased apoptosis of pulmonary epithelial cells is thought to play a role in COPD developmen... |
|
|
Polynucleotide phosphorylase exonuclease and polymerase activities on single-stranded DNA ends are modulated by RecN, SsbA and RecA proteins.
Nucleic Acids Res. 39(21) , 9250-61, (2011) Bacillus subtilis pnpA gene product, polynucleotide phosphorylase (PNPase), is involved in double-strand break (DSB) repair via homologous recombination (HR) or non-homologous end-joining (NHEJ). RecN is among the first responders to localize at the DNA DSBs,... |
|
|
Binary and ternary binding affinities between exonuclease-deficient Klenow fragment (Kf-exo(-)) and various arylamine DNA lesions characterized by surface plasmon resonance.
Chem. Res. Toxicol. 25(8) , 1568-70, (2012) We used surface plasmon resonance (SPR) to characterize the binding interactions between the exonulease-free Klenow fragment (Kf-exo(-)) and unmodified and modified dG adducts derived from arylamine carcinogens: fluorinated 2-aminofluorene (FAF), 2-acetylamin... |
|
|
Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase.
Nucleic Acids Res. 41(3) , 2060-71, (2013) Nitrated polycyclic aromatic hydrocarbons are common environmental pollutants, of which many are mutagenic and carcinogenic. 1-Nitropyrene is the most abundant nitrated polycyclic aromatic hydrocarbon, which causes DNA damage and is carcinogenic in experiment... |