D-Saccharic acid 1,4-lactone hydrate
D-Saccharic acid 1,4-lactone hydrate structure
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Common Name | D-Saccharic acid 1,4-lactone hydrate | ||
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| CAS Number | 61278-30-6 | Molecular Weight | 192.12400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H10O8 | Melting Point | 80-82ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.
Drug Metab. Dispos. 43(1) , 126-39, (2014) Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investigated phase II biotransformation of 11 test substrates in fr... |
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A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors.
Curr. Chem. Genomics 5 , 13-20, (2011) CPT-11 is a widely-used anti-cancer drug that is converted in vivo to its active metabolite, SN-38. In the liver, enzymes detoxify SN-38 by coupling it to a glucuronidate moiety and this inactive compound (SN-38G) is excreted into the gastrointestinal tract. ... |
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Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation.
Mol. Genet. Metab. 99(1) , 62-71, (2010) Here we report the characterization of a knock-in mouse model for the autosomal recessive disorder mucopolysaccharidosis type I-Hurler (MPS I-H), also known as Hurler syndrome. MPS I-H is the most severe form of alpha-l-iduronidase deficiency. alpha-l-iduroni... |