1,4-Diisocyanatobutane

1,4-Diisocyanatobutane Structure
1,4-Diisocyanatobutane structure
Common Name 1,4-Diisocyanatobutane
CAS Number 4538-37-8 Molecular Weight 140.140
Density 1.1±0.1 g/cm3 Boiling Point 220.5±0.0 °C at 760 mmHg
Molecular Formula C6H8N2O2 Melting Point 0ºC
MSDS Chinese USA Flash Point 106.7±0.0 °C
Symbol GHS07
GHS07
Signal Word Warning

Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors.

Bioorg. Med. Chem. Lett. 24(9) , 2193-7, (2014)

A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM. 1,6-(Hexamethylene)bis[(adamant-1-yl)urea] (3b) was found to be a potent s...