Folic Acid
Folic Acid structure
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Common Name | Folic Acid | ||
|---|---|---|---|---|
| CAS Number | 59-30-3 | Molecular Weight | 441.397 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C19H19N7O6 | Melting Point | 250 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging.
BMC Genomics 16 , 151, (2015) Leishmania use exosomes to communicate with their mammalian hosts and these secreted vesicles appear to contribute to pathogenesis by delivering protein virulence factors to macrophages. In other eukaryotes, exosomes were found to carry RNA cargo, such as mRN... |
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Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations.
J. Nutr. 145(1) , 79-86, (2015) Folates are essential cofactors in metabolic pathways that facilitate biological methylation and nucleotide synthesis, and therefore have widespread effects on health and diseases. Although obesity is prevalent worldwide, few studies have investigated how obe... |
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Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application.
Int. J. Pharm. 484(1-2) , 276-82, (2015) Stabilization of graphene oxide (GO) in physiological solution is performed using hydroxyethyl cellulose (HEC) to make the resultant nanohybrid suitable for targeted drug delivery purposes. Short and long term stability of GO suspensions with different ionic ... |
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Tissue vitamin concentrations are maintained constant by changing the urinary excretion rate of vitamins in rats' restricted food intake.
Biosci. Biotechnol. Biochem. 78(12) , 2102-9, (2014) We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vita... |
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Mitochondria apoptosis pathway synergistically activated by hierarchical targeted nanoparticles co-delivering siRNA and lonidamine.
Biomaterials 61 , 178-89, (2015) The mitochondria-mediated apoptosis pathway is an effective option for cancer therapy due to the presence of cell-suicide weapons in mitochondria. However, anti-apoptotic proteins that are over-expressed in the mitochondria of many malignant tumors, such as B... |
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Solubilization of gliadins for use as a source of nitrogen in the selection of bacteria with gliadinase activity.
Food Chem. 168 , 439-44, (2014) For patients with celiac disease, gliadin detoxification via the use of gliadinases may provide an alternative to a gluten-free diet. A culture medium, in which gliadins were the sole source of nitrogen, was developed for screening for microorganisms with gli... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Biomarkers of one-carbon metabolism are associated with biomarkers of inflammation in women.
J. Nutr. 144(5) , 714-21, (2014) Folate-mediated one-carbon metabolism is essential for DNA synthesis, repair, and methylation. Perturbations in one-carbon metabolism have been implicated in increased risk of some cancers and may also affect inflammatory processes. We investigated these inte... |
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Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival.
J. Natl. Cancer Inst. 106(12) , doi:10.1093/jnci/dju327, (2014) The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.The European Prospective Investigation into Cancer and Nutrition ... |