Digitonin
Digitonin structure
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Common Name | Digitonin | ||
|---|---|---|---|---|
| CAS Number | 11024-24-1 | Molecular Weight | 1229.312 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C56H92O29 | Melting Point | 230-240ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides.
Virology 476 , 168-79, (2015) Combinations of direct-acting antivirals (DAAs) against the hepatitis C virus (HCV) have the potential to revolutionize the HCV therapeutic regime. An integral component of DAA combination therapies is HCV NS5A inhibitors. It has previously been proposed that... |
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Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.
Toxicol. Appl. Pharmacol. 282(1) , 77-89, (2015) The intracellular level of bilirubin (BR), an endogenous antioxidant that is cytotoxic at high concentrations, is tightly controlled within the optimal therapeutic range. We have recently described a concerted intracellular BR regulation by two microsomal enz... |
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Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.
Nat. Commun. 6 , 6119, (2015) Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary to this view, we show here that TLR7 is present on the cell ... |
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Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.
PLoS ONE 9(11) , e112413, (2014) Parkinson disease (PD) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called Lewy bodies. Genetic predisposition, such as point mutations and copy number v... |
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Controlled Endolysosomal Release of Agents by pH-responsive Polymer Blend Particles.
Pharm. Res. 32 , 2280-91, (2015) A key step of delivering extracellular agents to its intracellular target is to escape from endosomal/lysosomal compartments, while minimizing the release of digestive enzymes that may compromise cellular functions. In this study, we examined the intracellula... |
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CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.
J. Exp. Med. 212 , 1465-79, (2015) The CCR4-NOT deadenylase complex plays crucial roles in mRNA decay and translational repression induced by poly(A) tail shortening. Although the in vitro activities of each component of this complex have been well characterized, its in vivo role in immune cel... |
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Correlation of disease activity in proliferative glomerulonephritis with glomerular spleen tyrosine kinase expression.
Kidney Int. 88 , 52-60, (2015) Spleen tyrosine kinase (SYK) is an important component of the intracellular signaling pathway for various immunoreceptors. Inhibition of SYK has shown promise in preclinical models of autoimmune and glomerular disease. However, the description of SYK expressi... |
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MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation.
Autophagy 11 , 1790-802, (2015) A reciprocal translocation of the ABL1 gene to the BCR gene results in the expression of the oncogenic BCR-ABL1 fusion protein, which characterizes human chronic myeloid leukemia (CML), a myeloproliferative disorder considered invariably fatal until the intro... |
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Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge.
PLoS ONE 9(10) , e111534, (2014) Chemotaxis is controlled by interactions between receptors, Rho-family GTPases, phosphatidylinositol 3-kinases, and cytoskeleton remodeling proteins. We investigated how the metastasis suppressor, SSeCKS, attenuates chemotaxis. Chemotaxis activity inversely c... |
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Piperine inhibits the growth and motility of triple-negative breast cancer cells.
Cancer Lett. 357(1) , 129-40, (2014) Piperine, an alkaloid from black pepper, is reported to have anticancer activities. In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (TNBC) cells. Piperine inhibited the in vitro growth of TNBC ... |