1-(3-Chlorophenyl)piperazine hydrochloride
1-(3-Chlorophenyl)piperazine hydrochloride structure
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Common Name | 1-(3-Chlorophenyl)piperazine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 65369-76-8 | Molecular Weight | 233.138 | |
| Density | 1.193g/cm | Boiling Point | 336.4ºC at 760 mmHg | |
| Molecular Formula | C10H14Cl2N2 | Melting Point | 210-214 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 157.2ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.
J. Pharmacol. Exp. Ther. 352(1) , 156-65, (2015) Nitrous oxide (N2O) gas is a widely used anesthetic adjunct in dentistry and medicine that is also commonly abused. Studies have shown that N2O alters the function of the N-methyl-d-aspartate (NMDA), GABAA, opioid, and serotonin receptors among others. Howeve... |
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Simultaneous Quantitation of 78 Drugs and Metabolites in Urine with a Dilute-And-Shoot LC-MS-MS Assay.
J. Anal. Toxicol. 39 , 335-46, (2015) A novel LC-MS-MS assay that simultaneously detects and quantitates 78 drugs and metabolites was developed and validated for chronic pain management. Urine specimen was diluted and mixed with internal standards (ISs) before injected into LC-MS-MS. Seventy-two ... |
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1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain.
Biol. Psychiatry 25(5) , 569-75, (1989) The affinity of 1-(m-chlorophenyl)piperazine (mCPP) for 11 neurotransmitter receptor binding sites was determined in human brain membranes. mCPP is essentially equipotent at all 5-hydroxytryptamine (5-HT) receptor subtypes (IC50 values ranging from 360 to 130... |
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Potencies of antagonists indicate that 5-HT1C receptors mediate 1-3(chlorophenyl)piperazine-induced hypophagia.
Br. J. Pharmacol. 103(4) , 2016-20, (1991) 1. 1-3(Chlorophenyl)piperazine (mCPP) (5 mg kg-1, i.p.) inhibited 2 h food intake in rats previously deprived of food for one day. Ten 5-hydroxytryptamine (5-HT) antagonists given s.c. opposed this hypophagic response. Calculated ID50 values correlated signif... |
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Detection of 1-benzylpiperazine and 1-(3-trifluoromethylphenyl)-piperazine in urine analysis specimens using GC-MS and LC-ESI-MS.
J. Anal. Toxicol. 32(6) , 444-50, (2008) Designer piperazines, such as 1-benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl)-piperazine (TFMPP), are widely available and have become popular party drugs throughout the world. Used in many countries as legal alternatives to methamphetamine and ecsta... |
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In vitro efficacy of new antiprotozoals against Philasterides dicentrarchi (Ciliophora, Scuticociliatida).
Dis. Aquat. Organ. 62(1-2) , 97-102, (2004) Philasterides dicentrarchi is a histiophagous ciliate that causes severe losses in turbot and sea bass farming. This study investigated the in vitro efficacy against P. dicentrarchi of 85 newly synthesized compounds and 12 commercial compounds, of which 2 are... |
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Serotonin modulates glutamatergic transmission to neurons in the lateral habenula.
Sci. Rep. 6 , 23798, (2016) The lateral habenula (LHb) is bilaterally connected with serotoninergic raphe nuclei, and expresses high density of serotonin receptors. However, actions of serotonin on the excitatory synaptic transmission to LHb neurons have not been thoroughly investigated... |
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Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR.
Cereb. Cortex 18 , 2646-58, (2008) Previous studies in the auditory cortex of Mongolian gerbils on discrimination learning of the direction of frequency-modulated tones (FMs) revealed that long-term memory formation involves activation of the dopaminergic system, activity of the protein kinase... |