Filipin III
Filipin III structure
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Common Name | Filipin III | ||
|---|---|---|---|---|
| CAS Number | 480-49-9 | Molecular Weight | 654.828 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 913.9±65.0 °C at 760 mmHg | |
| Molecular Formula | C35H58O11 | Melting Point | 163-180°C | |
| MSDS | Chinese USA | Flash Point | 279.3±27.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Cholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway.
PLoS ONE 8(2) , e55465, (2013) We have previously shown that soluble collagen and a human pathogen, echovirus 1 (EV1) cluster α2β1 integrin on the plasma membrane and cause their internalization into cytoplasmic endosomes. Here we show that cholesterol plays a major role not only in the up... |
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Analysis of cholesterol trafficking with fluorescent probes.
Methods Cell Biol. 108 , 367-93, (2012) Cholesterol plays an important role in determining the biophysical properties of biological membranes, and its concentration is tightly controlled by homeostatic processes. The intracellular transport of cholesterol among organelles is a key part of the homeo... |
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Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4.
Biochem. Biophys. Res. Commun. 456(1) , 312-9, (2015) TRPV4 is involved in several physiological and sensory functions as well as with several diseases and genetic disorders, though the molecular mechanisms for these are unclear. In this work we have analyzed molecular evolution and structure-function relationsh... |
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Brain region-specific immunolocalization of the lipolysis-stimulated lipoprotein receptor (LSR) and altered cholesterol distribution in aged LSR+/- mice.
J. Neurochem. 123(4) , 467-76, (2012) Brain lipid homeostasis is important for maintenance of brain cell function and synaptic communications, and is intimately linked to age-related cognitive decline. Because of the blood-brain barrier's limiting nature, this tissue relies on a complex system fo... |
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HaCaT keratinocytes exhibit a cholesterol and plasma membrane viscosity gradient during directed migration.
Exp. Cell Res. 318(7) , 809-18, (2012) Keratinocyte migration plays an important role in cutaneous wound healing by supporting the process of reepithelialisation. During directional migration cells develop a polarised shape with an asymmetric distribution of a variety of signalling molecules in th... |
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Enhanced phosphorylation of caveolar PKC-α limits peptide internalization in lung endothelial cells.
Mol. Cell Biochem. 360(1-2) , 309-20, (2012) We previously reported that the vasoactive peptide 1 (P1, "SSWRRKRKESS") modulates the tension of pulmonary artery vessels through caveolar endothelial nitric oxide synthase (eNOS) activation in intact lung endothelial cells (ECs). Since PKC-α is a caveolae r... |
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The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.
Microbiology 157(Pt 8) , 2266-75, (2011) The γ-butyrolactone autoregulator receptor has been shown to control secondary metabolism and/or morphological differentiation across many Streptomyces species. Streptomyces avermitilis produces an important anthelmintic agent (avermectin) and two further pol... |
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A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase.
Nat. Cell Biol. 15(1) , 50-60, (2013) Clathrin-mediated endocytosis is essential for a wide range of cellular functions. We used a multi-step siRNA-based screening strategy to identify regulators of the first step in clathrin-mediated endocytosis, formation of clathrin-coated vesicles (CCVs) at t... |
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Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice.
Atherosclerosis 223(2) , 332-41, (2012) The ABCA2 transporter shares high structural homology to ABCA1, which is crucial for the removal of excess cholesterol from macrophages and, by extension, in atherosclerosis. It has been suggested that ABCA2 sequesters cholesterol inside the lysosomes, howeve... |
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Internal structure consistent with remodelling in very small drusen, revealed by filipin histochemistry for esterified cholesterol.
Br. J. Ophthalmol. 98(5) , 698-702, (2014) Drusen, the pathognomonic lesion of age-related macular degeneration, are dynamic and undergo both growth and regression. Using histochemistry to localise esterified cholesterol (EC), we investigated small drusen to discover signs of dynamism.Flat mounts of B... |