Ac-Asp-Glu-Val-Asp-AMC ammonium salt

Ac-Asp-Glu-Val-Asp-AMC ammonium salt Structure
Ac-Asp-Glu-Val-Asp-AMC ammonium salt structure
Common Name Ac-Asp-Glu-Val-Asp-AMC ammonium salt
CAS Number 169332-61-0 Molecular Weight 675.641
Density 1.4±0.1 g/cm3 Boiling Point 1200.1±65.0 °C at 760 mmHg
Molecular Formula C30H37N5O13 Melting Point N/A
MSDS USA Flash Point 679.6±34.3 °C

RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status.

Eur. J. Cancer 51(7) , 841-51, (2015)

Mutant p53 can exert oncogenic activity by inhibitory interaction with p73. The small-molecule RETRA has been described to disrupt this interaction and to suppress carcinoma cells (Kravchenko et al., 2008). RETRA's anticancer activity was restricted to tumour...

Neuroprotection of atractylenolide III from Atractylodis macrocephalae against glutamate-induced neuronal apoptosis via inhibiting caspase signaling pathway.

Neurochem. Res. 39(9) , 1753-8, (2014)

Glutamate-induced excitotoxicity appears to play a crucial role in neurological disorders. Neuroprotection against glutamate-induced excitotoxicity has been proposed as a therapeutic strategy for preventing and/or treating these excitotoxicity-mediated diseas...

Synergistic apoptosis-inducing effects on A375 human melanoma cells of natural borneol and curcumin.

PLoS ONE 9(6) , e101277, (2014)

This study was to investigate the synergistic effect of NB/Cur on growth and apoptosis in A375 human melanoma cell line by MTT assay, flow cytometry and Western blotting. Our results demonstrated that NB effectively synergized with Cur to enhance its antiprol...

Gliotoxin potentiates osteoblast differentiation by inhibiting nuclear factor-κB signaling.

Mol. Med. Report. 12 , 877-84, (2015)

The differentiation of pluripotent mesenchymal stem cells to mature osteoblasts is crucial for the maintenance of the adult skeleton. In rheumatic arthritis, osteoblast differentiation is impaired by the overproduction of cytokine tumor necrosis factor (TNF)‑...

Heat shock protein-27 delays acute rejection after cardiac transplantation: an experimental model.

Transplantation 98(1) , 29-38, (2014)

Rejection is the major obstacle to survival after cardiac transplantation. We investigated whether overexpression of heat shock protein (Hsp)-27 in mouse hearts protects against acute rejection and the mechanisms of such protection.Hearts from B10.A mice over...

Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer.

Phytomedicine 22 , 1079-87, (2015)

Dihydrotanshinone I (DHTS) was previously reported to exhibit the most potent anti-cancer activity among several tanshinones in colon cancer cells. Its cytotoxic action was reactive oxygen species (ROS) dependent but p53 independent.To further study the anti-...

Distinct muscle apoptotic pathways are activated in muscles with different fiber types in a rat model of critical illness myopathy.

J. Muscle Res. Cell Motil. 36 , 243-53, (2015)

Critical illness myopathy (CIM) is associated with severe muscle atrophy and fatigue in affected patients. Apoptotic signaling is involved in atrophy and is elevated in muscles from patients with CIM. In this study we investigated underlying mechanisms of apo...

Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity.

Chem. Res. Toxicol. 28 , 1234-45, (2015)

Glycation, an endogenous process that leads to the production of advanced glycation end products (AGEs), plays a role in the etiopathogenesis of different neurodegenerative diseases, such as Alzheimer's disease (AD). Methylglyoxal is the most potent precursor...

Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis.

Drug Des. Devel. Ther. 8 , 583-600, (2014)

Caspases are currently known as the central executioners of the apoptotic pathways. Inhibition of apoptosis and promotion of normal cell survival by caspase inhibitors would be a tremendous benefit for reducing the side effects of cancer therapy and for contr...

Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma.

Oncotarget 6 , 15410-24, (2015)

Multiple myeloma (MM) is a hematological malignancy characterized by the aberrant accumulation of clonal plasma cells in the bone marrow. Despite recent advancement in anti-myeloma treatment, MM remains an incurable disease. This study showed higher intrinsic...