Disopyramide
Disopyramide structure
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Common Name | Disopyramide | ||
|---|---|---|---|---|
| CAS Number | 3737-09-5 | Molecular Weight | 339.47400 | |
| Density | 1.059g/cm3 | Boiling Point | 505.2ºC at 760mmHg | |
| Molecular Formula | C21H29N3O | Melting Point | 94.5-950C | |
| MSDS | N/A | Flash Point | 259.4ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains.
Behav. Brain Res. 274 , 1-9, (2014) The effect of glial cell line-derived neurotrophic factor (GDNF) on behavior and brain dopamine system in predisposed to depressive-like behavior ASC (Antidepressant Sensitive Cataleptics) mice in comparison with the parental "nondepressive" CBA mice was stud... |
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Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility.
Psychopharmacol. Ser. 232(1) , 39-46, (2015) The selective N-methyl-D-aspartate (NMDA) channel blocker MK-801 is known to induce no loss of the righting reflex (LORR) and to stimulate catecholaminergic (CAergic) neurons in rodents, playing a crucial role in arousal.We examined whether MK-801 in combinat... |
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A review of the effects of disopyramide phosphate on left ventricular function and the peripheral circulation.
Angiology 38(2 Pt 2) , 174-83, (1987) In the absence of preexistent myocardial dysfunction, the risk of producing cardiac decompensation in patients being treated with any of the conventional antiarrhythmic agents is low. The availability of disopyramide for clinical use in 1977 produced optimism... |
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[Hypoglycemia induced or facilitated by disopyramide].
Rev. Med. Interne 9(5) , 528-9, (1988)
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Effect of disopyramide on left ventricular pressure gradient in hypertrophic obstructive cardiomyopathy in comparison with propranolol--a case report.
Angiology 50(4) , 331-5, (1999) The effect of intravenous administration of disopyramide (total dose 100 mg, bolus 20 mg every 5 minutes) was compared with that of propranolol (total dose 10 mg, bolus 2 mg every 5 minutes) in a patient with hypertrophic obstructive cardiomyopathy. Left vent... |
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Fatal disopyramide intoxication from suicidal/accidental overdose.
J. Forensic Sci. 32(6) , 1813-8, (1987) Disopyramide is an oral antiarrhythmic drug which reduces conduction velocity, prolongs duration of action potential and the effective refractory period, and exerts vagolytic properties. The drug is usually well absorbed orally. The principal use of the drug ... |
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Disopyramide-induced hypoglycemia in a non-diabetic hemodialysis patient: a case report and review of the literature.
Clin. Nephrol. 76(5) , 401-6, (2011) Disopyramide, an antiarrhythmic drug, has been reported to cause hypoglycemia; however, its mechanism of action remains unclear. Pre-existing factors that increase the concentration of the drug in the blood increase the risk of hypoglycemia. Furthermore, othe... |
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[Effects of disopyramide on normal and pathological atrioventricular conduction].
Ann. Cardiol. Angeiol. (Paris.) 41(8) , 449-53, (1992) Disopyramide is a Vaughan-Williams class Ia antiarrhythmic, which is distinguished by its anticholinergic activity, which is due to its active metabolite: mono-N-alkyl disopyramide. In cells with a rapid response, such as those in the His-Purkinje tissue, it ... |
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[Hypoglycemia caused by disopyramide: physiopathology].
Ann. Med. Interne (Paris.) 146(3) , 209-10, (1995)
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[Severe hypoglycemia probably induced by disopyramide in a diabetic].
Therapie. 43(4) , 321-2, (1988)
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