D-erythro-Sphingosine
D-erythro-Sphingosine structure
|
Common Name | D-erythro-Sphingosine | ||
|---|---|---|---|---|
| CAS Number | 123-78-4 | Molecular Weight | 299.492 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 445.9±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H37NO2 | Melting Point | 81-82ºC | |
| MSDS | Chinese USA | Flash Point | 223.5±28.7 °C | |
|
Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer.
Breast Cancer Res. Treat. 149(1) , 59-67, (2015) Obesity is a known risk factor for breast cancer. We have recently identified that adipokine leptin regulates the expression of a proto-oncogenic enzyme sphingosine kinase 1 (SK1). Signal transducer and activator of transcription 3 (STAT3) has been linked to ... |
|
|
Sphingosine kinase 1 isoform-specific interactions in breast cancer.
Mol. Endocrinol. 28(11) , 1899-915, (2014) Sphingosine kinase 1 (SK1) is a signaling enzyme that catalyzes the formation of sphingosine-1-phosphate. Overexpression of SK1 is causally associated with breast cancer progression and resistance to therapy. SK1 inhibitors are currently being investigated as... |
|
|
Fungal metabolite myriocin promotes human herpes simplex virus-2 infection.
Life Sci. 120 , 31-8, (2015) Myriocin is a fungal metabolite with antiviral activity, including influenza, hepatitis B, and hepatitis C viruses. We investigated whether myriocin has activity against human HSV-2, one of the most prevalent pathogens of sexually transmitted disease.Cell cul... |
|
|
Regulation of SREBPs by Sphingomyelin in Adipocytes via a Caveolin and Ras-ERK-MAPK-CREB Signaling Pathway.
PLoS ONE 10 , e0133181, (2015) Sterol response element binding protein (SREBP) is a key transcription factor in insulin and glucose metabolism. We previously demonstrated that elevated levels of membrane sphingomyelin (SM) were related to peroxisome proliferator-activated receptor-γ (PPARγ... |
|
|
Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia.
Autophagy 11 , 653-69, (2015) Bioactive sphingolipids including ceramides are involved in a variety of pathophysiological processes by regulating cell death and survival. The objective of the current study was to examine ceramide metabolism in preeclampsia, a serious disorder of pregnancy... |
|
|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
|
|
Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.
Nat. Commun. 5 , 5514, (2014) Sphingosine is a major storage compound in Niemann-Pick type C disease (NP-C), although the pathological role(s) of this accumulation have not been fully characterized. Here we found that sphingosine kinase (SphK) activity is reduced in NP-C patient fibroblas... |
|
|
Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard.
Blood Cells Mol. Dis. 54(4) , 307-14, (2015) Deficiency of glucocerebrosidase (GBA) leads to Gaucher disease (GD), an inherited disorder characterised by storage of glucosylceramide (GlcCer) in lysosomes of tissue macrophages. Recently, we reported marked increases of deacylated GlcCer, named glucosylsp... |
|
|
Single-cell sphingosine kinase activity measurements in primary leukemia.
Anal. Bioanal. Chem 406(27) , 7027-36, (2014) Sphingosine kinase (SK) is a promising therapeutic target in a number of cancers, including leukemia. Traditionally, SK has been measured in bulk cell lysates, but this technique obscures the cellular heterogeneity present in this pathway. For this reason, SK... |
|
|
Regulation of mitochondrial ceramide distribution by members of the BCL-2 family.
J. Lipid Res. 56 , 1501-10, (2015) Apoptosis is an intricately regulated cellular process that proceeds through different cell type- and signal-dependent pathways. In the mitochondrial apoptotic program, mitochondrial outer membrane permeabilization by BCL-2 proteins leads to the release of ap... |