Mebeverine hydrochloride
Mebeverine hydrochloride structure
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Common Name | Mebeverine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 2753-45-9 | Molecular Weight | 466.01000 | |
| Density | N/A | Boiling Point | 543.8ºC at 760mmHg | |
| Molecular Formula | C25H36ClNO5 | Melting Point | 105-107ºC | |
| MSDS | Chinese USA | Flash Point | 282.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Validated chromatographic and spectrophotometric methods for analysis of some amoebicide drugs in their combined pharmaceutical preparation.
Pak. J. Pharm. Sci. 26(1) , 175-83, (2013) This work is concerned with development and validation of chromatographic and spectrophotometric methods for analysis of mebeverine HCl (MEH), diloxanide furoate (DF) and metronidazole (MET) in Dimetrol® tablets - spectrophotometric and RP-HPLC methods using ... |
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Preparation and in vitro evaluation of mebeverine HCl colon-targeted drug delivery system.
Pharm. Dev. Technol. 16(4) , 331-42, (2011) Mebeverine HCl is a water soluble drug commonly used to treat irritable bowel syndrome by acting directly on the smooth muscles of the colon. This work was aimed at the formulation and in vitro evaluation of a colon-targeted drug delivery system containing me... |
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Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines.
J. Pharm. Biomed. Anal. 54(4) , 646-52, (2011) An HPLC method for the quantitative analysis of mebeverine HCl, 5-aminosalicylic acid (5-ASA), sulphasalazine and dispersible aspirin has been developed and then applied to these specific medicines when stored, with other medications, in Venalink blister pack... |
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A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome.
World J. Gastroenterol. 16(5) , 547-53, (2010) We evaluated the efficacy and tolerability of mebeverine, a musculotropic antispasmodic agent, in irritable bowel syndrome (IBS) and compared its usual dosages by meta-analysis. Medical databases and all relevant literature were searched from 1965 to June 200... |
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Validated HPLC determination of the two fixed dose combinations (chlordiazepoxide hydrochloride and mebeverine hydrochloride; carvedilol and hydrochlorothiazide) in their tablets.
J. AOAC Int. 93(4) , 1192-200, (2010) Simple, rapid, and selective RP-HPLC methods with UV detection were developed for simultaneous determination of chlordiazepoxide hydrochloride and mebeverine hydrochloride (Mixture I) and carvedilol and hydrochlorothiazide (Mixture II). The chromatographic se... |
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First derivative synchronous fluorescence spectroscopy for the simultaneous determination of sulpiride and mebeverine hydrochloride in their combined tablets and application to real human plasma.
J. Fluoresc. 20(6) , 1275-85, (2010) A rapid, simple and highly sensitive first derivative synchronous fluorometric method has been developed for the simultaneous analysis of binary mixture of sulpiride (SUL) and mebeverine hydrochloride (MEB). The method is based upon measurement of the synchro... |
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Validated LC-MS/MS method for determination of Alverine and one of its hydroxy metabolites in human plasma along with its application to a bioequivalence study.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 197-206, (2009) The present research work involves a first of its kind rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method developed and validated for simultaneous analysis of Alverine (ALV) and one of its hydroxy metabolites, para hydroxy Al... |
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Management of irritable bowel syndrome in primary care: feasibility randomised controlled trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website. (MIBS trial).
BMC Gastroenterol. 10 , 136, (2010) IBS affects 10-22% of the UK population. Abdominal pain, bloating and altered bowel habit affect quality of life, social functioning and time off work. Current GP treatment relies on a positive diagnosis, reassurance, lifestyle advice and drug therapies, but ... |
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Support vector regression and artificial neural network models for stability indicating analysis of mebeverine hydrochloride and sulpiride mixtures in pharmaceutical preparation: a comparative study.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 86 , 515-26, (2012) A comparison between support vector regression (SVR) and Artificial Neural Networks (ANNs) multivariate regression methods is established showing the underlying algorithm for each and making a comparison between them to indicate the inherent advantages and li... |
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Fiber-based liquid-phase micro-extraction of mebeverine enantiomers followed by chiral high-performance liquid chromatography analysis and its application to pharmacokinetics study in rat plasma.
Chirality 24(8) , 634-9, (2012) The applicability of two-phase liquid-phase micro-extraction (LPME) in porous hollow polypropylene fiber for the sample preparation and the stereoselective pharmacokinetics of mebeverine (MEB) enantiomers (an antispasmodic drug) in rat after intramuscular adm... |