Ketamine hydrochloride
Ketamine hydrochloride structure
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Common Name | Ketamine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1867-66-9 | Molecular Weight | 274.186 | |
| Density | 1.17g/cm3 | Boiling Point | 363.8ºC at 760 mmHg | |
| Molecular Formula | C13H17Cl2NO | Melting Point | 262 - 263ºC | |
| MSDS | Chinese USA | Flash Point | 173.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The [18F]FDG μPET readout of a brain activation model to evaluate the metabotropic glutamate receptor 2 positive allosteric modulator JNJ-42153605.
J. Pharmacol. Exp. Ther. 350(2) , 375-86, (2014) Using [(18)F]fluorodeoxyglucose μ-positron emission tomography ([(18)F]FDG μPET), we compared subanesthetic doses of memantine and ketamine on their potential to induce increases in brain activation. We also studied the reversal effect of the well-known metab... |
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New paradigms for treatment-resistant depression.
Ann. N. Y. Acad. Sci. 1292(1) , 21-31, (2013) Clinical depression is a serious mental disorder characterized by low mood, anhedonia, loss of interest in daily activities, and other symptoms, and is associated with severe consequences including suicide and increased risk of cardiovascular events. Depressi... |
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(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function.
Anesthesiology 121(1) , 149-59, (2014) Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression. In the rat, the antidepressant effects of (R,S)-ketamine are associated with increased activity and function of mammalian target of rapamycin (mTOR); however, ... |
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Propofol with ketamine following sedation with xylazine for routine induction of general anaesthesia in horses.
Vet. Rec. 173(22) , 550, (2013) To document the suitability of intravenous propofol and ketamine following sedation with xylazine for routine anaesthetic induction in horses. Retrospective. 100 client-owned horses. Anaesthetic records were evaluated to determine: signalment, anaesthetic dru... |
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Disruption of frontal-parietal communication by ketamine, propofol, and sevoflurane.
Anesthesiology 118(6) , 1264-75, (2013) Directional connectivity from anterior to posterior brain regions (or "feedback" connectivity) has been shown to be inhibited by propofol and sevoflurane. In this study the authors tested the hypothesis that ketamine would also inhibit cortical feedback conne... |
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The study of consciousness comes of age.
Anesthesiology 118(6) , 1245-6, (2013)
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In reply: Propofol and additives in studies evaluating inflammatory responses.
J. Pediatr. Hematol. Oncol. 37(1) , 73-4, (2015)
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The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomised, double-blind, controlled study.
Anaesthesia 69(1) , 46-52, (2014) Ketamine and pregabalin each provide postoperative analgesia, although the combination has yet to be evaluated. One hundred and forty-two patients undergoing total hip arthroplasty were randomly assigned to receive ketamine alone, pregabalin alone, ketamine a... |
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Acute ketamine impairs mitochondrial function and promotes superoxide dismutase activity in the rat brain.
Anesth. Analg. 120(2) , 320-8, (2015) Ketamine is often associated with altered mitochondrial function and oxidative stress. Nevertheless, limited data are still available regarding the in vivo action of ketamine in mitochondrial bioenergetics and redox state. Accumulating evidence supports a rol... |
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Topically applied caffeine induces miosis in the ketamine/xylazine anesthetized rat.
Exp. Eye Res. 127 , 179-83, (2014) The aim of the present study was to examine if topically applied caffeine influences pupil size in ketamine/xylazine anesthetized animals. Two experiments were carried out. In the first experiment, caffeine was topically applied to one of the eyes of 10 ketam... |