Antazoline
Antazoline structure
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Common Name | Antazoline | ||
|---|---|---|---|---|
| CAS Number | 154-68-7 | Molecular Weight | 363.348 | |
| Density | 0.975 g/mL at 25 °C(lit.) | Boiling Point | 235-236 °C(lit.) | |
| Molecular Formula | C17H22N3O4P | Melting Point | 120-122ºC | |
| MSDS | Chinese USA | Flash Point | >230 °F | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.
Eur. J. Ophthalmol. 20(5) , 811-8, (2010) To compare the effects of topical antiallergic eyedrops in relieving the signs and symptoms of patients with allergic conjunctival pathology.In this multicenter, single-masked, randomized study, 240 patients with signs and symptoms of allergic conjunctivitis ... |
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Simultaneous determination of antazoline and naphazoline by the net analyte signal standard addition method and spectrophotometric technique.
J. AOAC Int. 93(6) , 1995-2001, (2010) A novel net analyte signal standard addition method (NASSAM) was used for simultaneous determination of the drugs anthazoline and naphazoline. The NASSAM can be applied for determination of analytes in the presence of known interferents. The proposed method i... |
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Determination of antihistamines based on the formation of mixed aggregates with surfactants.
Analyst 123(5) , 1079-84, (1998) The determination of antihistamines based on the measurement of the critical micelle concentration (c.m.c.) of mixed sodium dodecyl sulfate (SDS)-antihistamine aggregates is proposed. The dye Coomassie Brilliant Blue G (CBBG) was used as a photometric probe f... |
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A rapid derivative spectrophotometric method for simultaneous determination of naphazoline and antazoline in eye drops.
Chem. Pharm. Bull. 54(1) , 119-22, (2006) A zero-crossing first-derivative spectrophotometric method is applied for the simultaneous determination of naphazoline hydrochloride and antazoline phosphate in eye drops. The measurements were carried out at wavelengths of 225 and 252 nm for naphazoline hyd... |
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Clinical efficacy of antazoline in rapid cardioversion of paroxysmal atrial fibrillation--a protocol of a single center, randomized, double-blind, placebo-controlled study (the AnPAF Study).
Trials 13 , 162, (2012) Rapid conversion of atrial fibrillation (AF) to sinus rhythm may be achieved by the administration of class IA, IC and III antiarrhythmic drugs or vernakalant hydrochloride. However, that treatment may be related to potential pro-arrhythmia, lack of efficacy ... |
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Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic beta-cells.
Naunyn Schmiedebergs Arch. Pharmacol. 361(2) , 146-54, (2000) Pancreatic beta-cells express imidazoline binding sites which play a role in the regulation of insulin secretion, but it is not known whether ligands for these sites also affect other aspects of beta-cell physiology. In the present study, we have investigated... |
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Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus.
Neuroscience 120(2) , 475-84, (2003) Imidazoline drugs exert neuroprotective effects in cerebral ischaemia models. They also have effects against mouse cerebellar and striatal neuronal death induced by N-methyl-D-aspartate (NMDA) through the blockade of NMDA currents. Here, we investigated the e... |
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Effect of histamine receptor antagonists on aminophylline-induced seizures and lethality in mice.
Pharmacol. Rep. 57(4) , 531-5, (2005) The aim of this study was to evaluate the effects of H(1) (antazoline and astemizole) or H(2) (cimetidine and famotidine) histamine receptor antagonists on the clonic phase, tonic seizures and morality of mice challenged with aminophylline to induce convulsio... |
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Inhibition of voltage-gated Ca2+ channels by antazoline.
Neuroreport 13(14) , 1711-4, (2002) We showed recently that imidazolines exert neuroprotection against hypoxia and NMDA toxicity in cerebellar and striatal neuronal cultures, through a voltage-dependent blockade of glutamatergic NMDA receptors. Here, we report that in striatal neuronal cultures... |
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[Antazoline/tetryzoline eyedrops in comparison with levocabastine eyedrops in acute allergic conjunctivitis].
Klin. Monbl. Augenheilkd. 210(2) , 93-6, (1997) Allergic conjunctivitis is one of the most frequent allergic diseases of the anterior eye segment.This multicentre, clinical trial was an investigation to compare the antiallergic efficacy, local tolerance and safety of Antazolin/Tetryzolin eye drops and Levo... |