Noscapine
Noscapine structure
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Common Name | Noscapine | ||
|---|---|---|---|---|
| CAS Number | 128-62-1 | Molecular Weight | 413.421 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 565.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H23NO7 | Melting Point | 174-176ºC | |
| MSDS | N/A | Flash Point | 295.7±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Determinants of increased opioid-related mortality in the United States and Canada, 1990-2013: a systematic review.
Am. J. Public Health 104(8) , e32-42, (2014) We review evidence of determinants contributing to increased opioid-related mortality in the United States and Canada between 1990 and 2013. We identified 17 determinants of opioid-related mortality and mortality increases that we classified into 3 categories... |
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Adlumiceine methyl ester, a new alkaloid from Fumaria vaillantii.
J. Asian Nat. Prod. Res. 16(12) , 1148-52, (2014) A new alkaloid, adlumiceine methyl ester (1), together with two known alkaloids, parfumine (2) and N-methylhydrastine methyl ester (3), was isolated from aerial parts of Fumaria vaillantii. The structures of compounds were determined by 1D/2D NMR and MS data.... |
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Peloruside, laulimalide, and noscapine interactions with beta-tubulin.
Pharm. Res. 29(11) , 2985-93, (2012) This article reviews the recent findings regarding the binding sites, binding modes and binding affinities of three novel antimitotic drugs peloruside, laulimalide and noscapine with respect to tubulin as the target of their action. These natural compounds ar... |
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The anti-cancer activity of noscapine: a review.
Recent Pat. Anticancer. Drug Discov. 4(1) , 92-7, (2009) Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, noscapine is not sedative and has been used as antitussive drug in various countries. Recently, it has been introduced as an anti-mitotic agent.... |
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Implications of nanoscale based drug delivery systems in delivery and targeting tubulin binding agent, noscapine in cancer cells.
Curr. Drug Metab. 13(10) , 1476-83, (2012) Noscapine, a tubulin binding anticancer agent undergoing Phase I/II clinical trials, inhibits tumor growth in nude mice bearing human xenografts of breast, lung, ovarian, brain, and prostrate origin. The analogues of noscapine like 9-bromonoscapine (EM011) ar... |
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A review on noscapine, and its impact on heme metabolism.
Curr. Drug Metab. 14(3) , 351-60, (2013) This review introduces the Noscapine, which is being used as an antitussive drug for a long time has been recently discovered as a novel tubulin-binding, anti-angiogenic anticancer drug that causes cell cycle arrest and induces apoptosis in cancer cells both ... |
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Noscapine may increase the effect of warfarin.
Br. J. Clin. Pharmacol. 65(2) , 277-8, (2008)
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