Montelukast sodium
Montelukast sodium structure
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Common Name | Montelukast sodium | ||
|---|---|---|---|---|
| CAS Number | 151767-02-1 | Molecular Weight | 608.165 | |
| Density | N/A | Boiling Point | 750.5ºC at 760mmHg | |
| Molecular Formula | C35H35ClNNaO3S | Melting Point | 115 °C(dec.) | |
| MSDS | Chinese USA | Flash Point | 407.7ºC | |
| Symbol |
GHS05, GHS08 |
Signal Word | Danger | |
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An evaluation of prophylactic treatments to prevent post traumatic joint stiffness.
J. Orthop. Res. 32(11) , 1520-4, (2014) Arthrofibrosis is a major obstacle to restoring joint function after trauma. The objective of this study was to evaluate montelukast, forskolin, and triamcinolone as possible means of prophylaxis against the formation of arthrofibrosis. Forty-eight rats under... |
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Biodegradable injectable in situ implants and microparticles for sustained release of montelukast: in vitro release, pharmacokinetics, and stability.
AAPS PharmSciTech 15(3) , 772-80, (2014) The objective of this study was to investigate the sustained release of a hydrophilic drug, montelukast (MK), from two biodegradable polymeric drug delivery systems, in situ implant (ISI) and in situ microparticles (ISM). N-Methyl pyrrolidone (NMP), dimethyl ... |
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Osmotically controlled pulsatile release capsule of montelukast sodium for chronotherapy: statistical optimization, in vitro and in vivo evaluation.
Drug Deliv. 21(7) , 509-18, (2014) The purpose of present study was to design, optimize and evaluate osmotically controlled pulsatile release capsule (PRC) of montelukast sodium (MKS) for the prevention of episodic attack of asthma in early morning and associated allergic rhinitis. Assembly of... |
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Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea.
Eur. J. Pediatr. 174(4) , 509-18, (2015) This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONME... |
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Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study
Ann. Allergy Asthma Immunol. 112(4) , 376-82, (2014) Background Observational reports have linked vitamin D with chronic urticaria, yet no randomized controlled trial has been conducted. |
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Flushing, fatigue, and recurrent anaphylaxis: a delayed diagnosis of mastocytosis
Lancet 383(9928) , 1608, (2014)
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Role of cysteinyl leukotriene signaling in a mouse model of noise-induced cochlear injury.
Proc. Natl. Acad. Sci. U. S. A. 111(27) , 9911-6, (2014) Noise-induced hearing loss is one of the most common types of sensorineural hearing loss. In this study, we examined the expression and localization of leukotriene receptors and their respective changes in the cochlea after hazardous noise exposure. We found ... |
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Protective effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against intestinal ischemia-reperfusion injury in the rat.
Acta Chir. Belg. 113(6) , 401-5, (2013) Ischemia-reperfusion (I-R) injury of the intestine is a significant problem because the initial damage caused by ischemia is exacerbated by reperfusion. In this study, we examined the protective effect of montelukast against I-R-induced intestinal tissue dama... |
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Restoration of the normal Clara cell phenotype after chronic allergic inflammation.
Int. J. Exp. Pathol. 94(6) , 399-411, (2013) Bronchiolar Clara cells play a critical role in lung homoeostasis. The main goal of this study was to evaluate the effects of chronic allergy on these cells and the efficacy of budesonide (BUD) and montelukast (MK) in restoring their typical phenotypes after ... |
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Low-level environmental tobacco smoke exposure and inflammatory biomarkers in children with asthma.
J. Asthma 51(4) , 355-9, (2014) The effects of low-level environmental tobacco smoke (ETS) exposure, on asthma control, lung function and inflammatory biomarkers in children with asthma have not been well studied. The objective of the study was to assess ETS exposure in school-age children ... |