Repaglinide
Repaglinide structure
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Common Name | Repaglinide | ||
|---|---|---|---|---|
| CAS Number | 135062-02-1 | Molecular Weight | 452.586 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 672.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C27H36N2O4 | Melting Point | 129-130.2 °C | |
| MSDS | Chinese USA | Flash Point | 360.8±31.5 °C | |
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[symbol: see text] Nateglinide and [symbol: see text] repaglinide for type 2 diabetes?
Drug Ther. Bull. 41(7) , 52-4, (2003) [symbol: see text] Nateglinide (Starlix-Novartis) and [symbol: see text] repaglinide (NovoNorm-Novo Nordisk) are two of a new class of orally active antidiabetic drugs, the meglitinides. They have a rapid-onset and short-lasting stimulating effect on insulin ... |
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Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide.
Clin. Pharmacokinet. 46(2) , 93-108, (2007) This review describes the current knowledge on drug-drug and food-drug interactions with repaglinide and nateglinide. These two meglitinide derivatives, commonly called glinides, have been developed for improving insulin secretion of patients with type 2 diab... |
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Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.
Drug Metab. Dispos. 41(2) , 362-71, (2013) The plasma concentration of repaglinide is reported to increase greatly when given after repeated oral administration of itraconazole and gemfibrozil. The present study analyzed this interaction based on a physiologically based pharmacokinetic (PBPK) model in... |
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Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide.
Pharm. Res. 30(4) , 1188-99, (2013) Quantitative prediction of complex drug-drug interactions (DDIs) is challenging. Repaglinide is mainly metabolized by cytochrome-P-450 (CYP)2C8 and CYP3A4, and is also a substrate of organic anion transporting polypeptide (OATP)1B1. The purpose is to develop ... |
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CYP2C metabolism of oral antidiabetic drugs--impact on pharmacokinetics, drug interactions and pharmacogenetic aspects.
Expert Opin. Drug Metab. Toxicol. 8(12) , 1549-63, (2012) The cytochrome P4502C enzymes account for the metabolism of approximately 20% of therapeutic drugs including certain oral antidiabetic drugs (OADs).This review focuses on the effect of CYP2C enzymes on metabolism of sulphonylureas (SUs), meglitinides, and thi... |
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Applications of minimal physiologically-based pharmacokinetic models.
J. Pharmacokinet. Pharmacodyn. 39(6) , 711-23, (2012) Conventional mammillary models are frequently used for pharmacokinetic (PK) analysis when only blood or plasma data are available. Such models depend on the quality of the drug disposition data and have vague biological features. An alternative minimal-physio... |
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The Influence of MDR1 G2677T/a genetic polymorphisms on the pharmacokinetics of repaglinide in healthy Chinese volunteers.
Pharmacology 89(1-2) , 105-10, (2012) The aim of this study was to evaluate the pharmacogenetic variability in the disposition of repaglinide in healthy Chinese subjects.A single dose of 2 mg repaglinide was orally administered to 24 healthy Chinese subjects. The serum concentrations of repaglini... |
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Oral combination therapy: repaglinide plus metformin for treatment of type 2 diabetes.
Diabetes Obes. Metab. 10(12) , 1167-77, (2008) Type 2 diabetes is characterized by decreases in insulin secretion and insulin sensitivity. Several classes of oral antidiabetic medications are currently approved for the treatment of type 2 diabetes. A stepwise treatment approach from monotherapy to combina... |
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LC-MS/MS-ESI method for simultaneous quantitation of metformin and repaglinidie in rat plasma and its application to pharmacokinetic study in rats.
Biomed. Chromatogr. 27(3) , 356-64, (2013) A highly sensitive and specific LC-MS/MS-ESI method has been developed for simultaneous quantification of metformin (MFN) and repaglinide (RGN) in rat plasma (50 μL) using phenacetin as an internal standard (IS). Simple protein precipitation was used to extra... |
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Repaglinide: prandial glucose regulation in clinical practice.
Diabetes Obes. Metab. 2 Suppl 1 , S43-8, (2000) Prandial glucose regulation represents a new concept in the management of type 2 diabetes: targeting postprandial glycaemic excursions as a means of achieving long-term glycaemic control. Although control of the overall glycaemic load is the most important fa... |