3-PHTHALODINITRILE

3-PHTHALODINITRILE Structure
3-PHTHALODINITRILE structure
Common Name 3-PHTHALODINITRILE
CAS Number 2317-22-8 Molecular Weight 142.15700
Density 1.12g/cm3 Boiling Point 125-130ºC2 mm Hg(lit.)
Molecular Formula C9H6N2 Melting Point 135-137ºC(lit.)
MSDS Chinese USA Flash Point 117.2ºC
Symbol GHS07
GHS07
Signal Word Warning

Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP).

Bioorg. Med. Chem. 6(6) , 721-34, (1998)

Inhibitors of poly(ADP-ribose)polymerase (PARP) inhibit repair of damaged DNA and thus potentiate radiotherapy and chemotherapy of cancer. 3-Substituted benzamides and 5-substituted isoquinolin-1-ones have been synthesised and evaluated for inhibition of PARP...