2,4-Dihydroxybenzoic acid
2,4-Dihydroxybenzoic acid structure
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Common Name | 2,4-Dihydroxybenzoic acid | ||
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| CAS Number | 89-86-1 | Molecular Weight | 154.120 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 414.8±15.0 °C at 760 mmHg | |
| Molecular Formula | C7H6O4 | Melting Point | 208-211 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 218.8±16.9 °C | |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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Application of Electrochemiluminescence for the Evaluation of the Antioxidant Capacity of Some Phenolic Compounds Against Superoxide Anion Radicals.
Anal. Sci. 31 , 629-34, (2015) This paper for the first time reports on novel and non-enzymatic method for studying the free radical-scavenging properties of phenolic compounds against superoxide anion radicals (O2·(-)) by using the cathodic electrochemiluminescence (ECL) of lucigenin (Luc... |
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3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors.
Bioorg. Med. Chem. 15 , 2006-15, (2007) Phenoloxidase (PO), also known as tyrosinase, is a key enzyme in insect development, responsible for catalyzing the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-quinones. Inhibition of PO may provide a basis for novel env... |
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Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids.
Bioorg. Med. Chem. 16 , 4589-93, (2008) Elevated levels of phospholipases, prostaglandin synthases and lipoxygenases in colonic cells at various stages of malignancy indicate a strong link between dietary lipids and colon cancer. Lipoxygenase-catalysed arachidonic acid metabolism plays a key role i... |
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Application of capillary electrophoresis with electrokinetic supercharging and sweeping for the on-line preconcentration of phenolic acids.
Anal. Bioanal. Chem 407 , 7093-100, (2015) Phenolic acids are natural antioxidants. Many studies have confirmed that these compounds can reduce the risk of developing chronic diseases such as diabetes, cardiovascular diseases, and certain cancers. In this work, we developed a rapid and efficient capil... |
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High efficiency polyethylene glycol diacrylate monoliths for reversed-phase capillary liquid chromatography of small molecules.
J. Chromatogr. A. 1364 , 96-106, (2014) Highly cross-linked monolithic networks (i.e., polyethylene glycol diacrylate, PEGDA) synthesized from monomers containing varying ethylene oxide chain lengths were fabricated inside fused silica capillary columns for use in liquid chromatography (LC) of smal... |
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Absorption spectra of radicals of substrates for p-hydroxybenzoate hydroxylase following electrophilic attack of the .OH radical in the 3 position.
J. Biol. Chem. 262(36) , 17475-9, (1987) The spectra of radicals formed upon the addition of .OH radicals to the 3 position of substrates for p-hydroxybenzoate hydroxylase (4-hydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 4-aminobenzoic acid) have been determined using pulse radiolysis combined... |
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Degradation of 2,4-dihydroxybenzoate by Pseudomonas sp. BN9.
FEMS Microbiol. Lett. 108(2) , 219-24, (1993) The aerobic degradation of 2,4-dihydroxybenzoate by Pseudomonas sp. BN9 was studied. Intact cells of Pseudomonas sp. BN9 grown with 2,4-dihydroxybenzoate oxidized 2,4-dihydroxybenzoate but not salicylate. Cell-free extracts of Pseudomonas sp. BN9 converted 2,... |
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Direct screening of G-quadruplex ligands from Kalopanax septemlobus (Thunb.) Koidz extract by high performance liquid chromatography.
J. Chromatogr. A. 1218(37) , 6433-8, (2011) G-quadruplex DNA structure is considered to be a very attractive target for antitumor drug design due to its unique role in maintaining telomerase activities. Therefore, discovering ligands with high stability of G-quadruplex structure is of great interest. I... |
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Absorption spectra of radical forms of 2,4-dihydroxybenzoic acid, a substrate for p-hydroxybenzoate hydroxylase.
J. Biol. Chem. 266(20) , 13086-90, (1991) Combined optical and conductimetric measurements in aqueous solution indicate that at high pH (greater than or equal to 10).OH radicals react with the phenoxide form of 2,4-dihydroxybenzoic acid to form transiently phenoxyl radicals and a small amount of hydr... |