2,6-Dihydroxypurine
2,6-Dihydroxypurine structure
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Common Name | 2,6-Dihydroxypurine | ||
|---|---|---|---|---|
| CAS Number | 69-89-6 | Molecular Weight | 152.111 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 834.9ºC at 760 mmHg | |
| Molecular Formula | C5H4N4O2 | Melting Point | 300 °C | |
| MSDS | Chinese USA | Flash Point | 458.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.
Naunyn Schmiedebergs Arch. Pharmacol. 387(9) , 849-59, (2014) Elevated polyol pathway enzyme activities and oxidative stress play an important role in the development and progression of diabetic nephropathy. Here, we investigated the beneficial influence of nigerloxin, a fungal metabolite and a potent aldose reductase i... |
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Antioxidant Capacities and Analysis of Phenolic Compounds in Three Endemic Nolana Species by HPLC-PDA-ESI-MS.
Molecules 20 , 11490-507, (2015) The antioxidant features, polyphenolic composition and chromatographic fingerprints of the aerial parts from three Chilean endemic plants from the Paposo Valley located on the cost of the Atacama Desert were investigated for the first time using high pressure... |
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Spironolactone and dimethylsulfoxide effect on glucose metabolism and oxidative stress markers in polycystic ovarian syndrome rat model.
Exp. Clin. Endocrinol. Diabetes 122(3) , 154-62, (2014) Because polycystic ovarian syndrome (PCOS) is a risk factor for type 2 diabetes, the affected women can present frequently prediabetic states such as impaired fasting glycaemia and/or impaired glucose tolerance. The purpose of our study is to explore the effe... |
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In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells.
PLoS ONE 10 , e0134768, (2015) Dapsone (DDS) hydroxylamine metabolites cause oxidative stress- linked adverse effects in patients, such as methemoglobin formation and DNA damage. This study evaluated the ameliorating effect of the antioxidant resveratrol (RSV) on DDS hydroxylamine (DDS-NHO... |
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In vitro Xanthine Oxidase Inhibitory Studies of Lippia nodiflora and Isolated Flavonoids and Phenylethanoid Glycosides as Potential Uric Acid-lowering Agents.
Nat. Prod. Commun. 10 , 945-8, (2015) Lippia nodiflora has been traditionally used for treatment of knee joint pain. Hitherto, no studies have been reported on the effective use of L. nodiflora against hyperuricemia, gout or other metabolic disorders. In this present study, L. nodiflora was exami... |
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Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377.
Free Radic. Biol. Med. 83 , 214-26, (2015) High dietary fructose is an important causative factor in the development of metabolic syndrome-associated glomerular podocyte oxidative stress and injury. Here, we identified microRNA-377 (miR-377) as a biomarker of oxidative stress in renal cortex of fructo... |
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Oxidative DNA damage in kidneys and heart of hypertensive mice is prevented by blocking angiotensin II and aldosterone receptors.
PLoS ONE 9(12) , e115715, (2015) Recently, we could show that angiotensin II, the reactive peptide of the blood pressure-regulating renin-angiotensin-aldosterone-system, causes the formation of reactive oxygen species and DNA damage in kidneys and hearts of hypertensive mice. To further inve... |
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Antifilarial effect of ursolic acid from Nyctanthes arbortristis: molecular and biochemical evidences.
Parasitol. Int. 63(5) , 717-28, (2014) A bio-assay guided fractionation and purification approach was used to examine in vitro antifilarial activities of the crude methanolic extract of Nyctanthes arbortristis as well as fractions and isolated compound. From ethyl-acetate fraction we isolated and ... |
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Oxidative/antioxidative enzyme-mediated antiproliferative and proapoptotic effects of the GPER1 agonist G-1 on lung cancer cells.
Oncol. Lett. 10(5) , 3177-3182, (2015) Estrogen mediates fast signal responses or transcriptional events via G protein-coupled estrogen receptor 1 (GPER1). However, there is no data on the effect of GPER1 on lung cancer cell proliferation and apoptosis. The present study aimed to analyze the antic... |
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Anthocyanins and antioxidant capacities of six Chilean berries by HPLC-HR-ESI-ToF-MS.
Food Chem. 176 , 106-14, (2015) The HPLC profiles of six fruits endemic of the VIII region of Chile were investigated using high resolution mass analysis (HR-ToF-ESI-MS). The anthocyanin fingerprints generated for the fruits were compared and the antioxidant capacities measured by the scave... |