Artemisinin
Artemisinin structure
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Common Name | Artemisinin | ||
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| CAS Number | 63968-64-9 | Molecular Weight | 282.332 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 389.9±42.0 °C at 760 mmHg | |
| Molecular Formula | C15H22O5 | Melting Point | 156-157ºC | |
| MSDS | Chinese USA | Flash Point | 172.0±27.9 °C | |
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Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.
Korean J. Physiol. Pharmacol. 19(1) , 21-7, (2015) The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the... |
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Artemisinin nanoformulation suitable for intravenous injection: Preparation, characterization and antimalarial activities.
Int. J. Pharm. 495 , 671-9, (2015) More than 40 years after its discovery, artemisinin has become the most promising antimalarial agent. However, no intravenous formulation is available due to its poor aqueous solubility. Here, we report the preparation, characterization, and in vitro and in v... |
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Self-assembled biotransesterified cyclodextrins as potential Artemisinin nanocarriers. II: In vitro behavior toward the immune system and in vivo biodistribution assessment of unloaded nanoparticles.
Eur. J. Pharm. Biopharm. 88(3) , 683-94, (2014) In a previous study, we reported on the formulation of Artemisinin-loaded surface-decorated nanoparticles (nanospheres and nanoreservoirs) by co-nanoprecipitation of PEG derivatives (PEG1500 and PEG4000-stearate, polysorbate 80) and biosynthesized γ-CD fatty ... |
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In vitro antitrypanosomal and antiplasmodial activities of crude extracts and essential oils of Ocimum gratissimum Linn from Benin and influence of vegetative stage.
J. Ethnopharmacol. 155(3) , 1417-23, (2014) Different parts of Ocimum gratissimum Linn are largely used in folk medicine for the treatment of many diseases, some of which related to parasitical infections as fevers and headaches. In order to validate their use and to clarify the plant part which posses... |
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Sperm characteristics, antioxidant status and hormonal profile in rats treated with artemisinin.
Andrologia 46(8) , 893-901, (2014) The indiscriminate use, abuse and patients' noncompliance to normal prescription of artemisinin and its derivatives are a common practice during the treatment for drug-resistant malaria parasites in most developing countries. This study investigated the influ... |
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Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.
Xenobiotica 44(7) , 615-26, (2014) 1. Cytochrome P450 enzyme system is the most important contributor to oxidative metabolism of drugs. Modification, and more specifically inhibition, of this system is an important determinant of several drug-drug interactions (DDIs). 2. Effects of the antimal... |
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Multivariate data analysis and metabolic profiling of artemisinin and related compounds in high yielding varieties of Artemisia annua field-grown in Madagascar.
J. Pharm. Biomed. Anal. 117 , 522-31, (2015) An improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) protocol for rapid analysis of co-metabolites of A. annua in raw extracts was developed and extensively characterized. The new method was used to analyse metabolic profiles of 13 varieties ... |
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Pharmacokinetics and tissue distribution study of novel potent antiplatelet agent S007-867 in mice using HPLC-MS/MS.
Xenobiotica 45 , 530-7, (2015) 1. S007-867 is a novel antiplatelet agent that shows promising in vitro and in vivo efficacy. For further development and better pharmacological elucidation, we characterized pharmacokinetics and tissue distribution of S007-867 in a mouse model. 2. A sensitiv... |
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Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives.
Acta Trop. 140 , 77-83, (2014) Malaria remains one of the world's most common infectious diseases, being responsible for more deaths than any other communicable disease except tuberculosis. There is strong evidence that tumour necrosis factor α and interleukin-1β are important contributors... |
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Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity.
Malaria Journal 13 , 359, (2014) Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolism, and excretion. ATP binding cassette (ABC) transport prot... |