DiSBAC2(5)
DiSBAC2(5) structure
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Common Name | DiSBAC2(5) | ||
|---|---|---|---|---|
| CAS Number | 70363-83-6 | Molecular Weight | 516.63 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H40N4O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer.
J. Pharmacol. Exp. Ther. 353(2) , 392-404, (2015) Therapy for treatment-resistant breast cancer provides limited options and the response rates are low. Therefore, the development of therapies with alternative chemotherapeutic strategies is necessary. AG311 (5-[(4-methylphenyl)thio]-9H-pyrimido[4,5-b]indole-... |
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AtCNGC2 is involved in jasmonic acid-induced calcium mobilization.
J. Exp. Bot. 67 , 809-19, (2016) Calcium (Ca(2+)) mobilization is a central theme in various plant signal transduction pathways. We demonstrate that Arabidopsis thaliana cyclic nucleotide-gated channel 2 (AtCNGC2) is involved in jasmonic acid (JA)-induced apoplastic Ca(2+) influx in Arabidop... |
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Simultaneous production of lactobionic and gluconic acid in cheese whey/glucose co-fermentation by Pseudomonas taetrolens.
Bioresour. Technol. 196 , 314-23, (2015) Substrate versatility of Pseudomonas taetrolens was evaluated for the first time in a co-fermentation system combining cheese whey and glucose, glycerol or lactose as co-substrates. Results showed that P. taetrolens displayed different production patterns dep... |
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Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.
Eur. J. Med. Chem. 89 , 362-9, (2014) Nine novel symmetrical bispyridinium cyclophanes have been synthesized. They are rigid derivatives with an upper spacer which joins the two exocyclic amino groups, and a lower spacer joining the two positively charged nitrogen atoms. At least one of the two s... |
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Upregulation of KCa3.1 K(+) channel in mesenteric lymph node CD4(+) T lymphocytes from a mouse model of dextran sodium sulfate-induced inflammatory bowel disease.
Am. J. Physiol. Gastrointest. Liver Physiol. 306(10) , G873-85, (2014) The intermediate-conductance Ca(2+)-activated K(+) channel KCa3.1/KCNN4 plays an important role in the modulation of Ca(2+) signaling through the control of the membrane potential in T lymphocytes. Here, we study the involvement of KCa3.1 in the enlargement o... |
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BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway.
Oncol. Rep. 33(2) , 533-8, (2014) In breast cancers, the large conductance Ca2+ and voltage sensitive K+ (BKCa) channels have been hypothesized to function as oncoproteins, yet it remains unclear how inhibition of channel activity impacts oncogenesis. We demonstrated herein that iberiotoxin (... |
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Type AII lantibiotic bovicin HJ50 with a rare disulfide bond: structure, structure-activity relationships and mode of action.
Biochem. J. 461(3) , 497-508, (2014) Lantibiotics are ribosomally synthesized antimicrobial peptides containing unusual amino acids. As promising alternatives to conventional antibiotics, they have a high potential for alleviating the problem of emergent antibiotic resistance, with possible appl... |
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AmgRS-mediated envelope stress-inducible expression of the mexXY multidrug efflux operon of Pseudomonas aeruginosa.
Microbiologyopen 4(1) , 121-35, (2015) AmgRS is an envelope stress-responsive two-component system and aminoglycoside resistance determinant in Pseudomonas aeruginosa that is proposed to protect cells from membrane damage caused by aminoglycoside-generated mistranslated polypeptides. Consistent wi... |
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Oral dosing of chemical indicators for in vivo monitoring of Ca2+ dynamics in insect muscle.
PLoS ONE 10(1) , e0116655, (2015) This paper proposes a remarkably facile staining protocol to visually investigate dynamic physiological events in insect tissues. We attempted to monitor Ca2+ dynamics during contraction of electrically stimulated living muscle. Advances in circuit miniaturiz... |
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A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes.
FASEB J. 29 , 3228-37, (2015) Discovery of novel drug targets may lead to improved treatment of trypanosomiasis. We characterize here 2 gene products of Trypanosoma brucei that are essential for the growth of bloodstream form (BSF) parasites, as shown by RNA interference (RNAi)-mediated d... |