1-Bromo-3-chloropropane

1-Bromo-3-chloropropane Structure
1-Bromo-3-chloropropane structure
Common Name 1-Bromo-3-chloropropane
CAS Number 109-70-6 Molecular Weight 157.437
Density 1.5±0.1 g/cm3 Boiling Point 136.4±13.0 °C at 760 mmHg
Molecular Formula C3H6BrCl Melting Point -59 °C
MSDS Chinese USA Flash Point 38.0±9.9 °C
Symbol GHS02 GHS06
GHS02, GHS06
Signal Word Danger

SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression.

Nucleic Acids Res. 42(18) , 11433-46, (2014)

Polycomb group (PcG) complexes regulate cellular identity through epigenetic programming of chromatin. Here, we show that SSX2, a germline-specific protein ectopically expressed in melanoma and other types of human cancers, is a chromatin-associated protein t...

Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma.

Blood Cancer J. 5 , e312, (2015)

Immunomodulatory drugs (IMiDs) thalidomide, lenalidomide (Len) and pomalidomide trigger anti-tumor activities in multiple myeloma (MM) by targetting cereblon and thereby impacting IZF1/3, c-Myc and IRF4. Histone deacetylase inhibitors (HDACi) also downregulat...

Contribution of the non-effector members of the HrpL regulon, iaaL and matE, to the virulence of Pseudomonas syringae pv. tomato DC3000 in tomato plants.

BMC Microbiol. 15 , 165, (2015)

The phytohormone indole-3-acetic acid (IAA) is widely distributed among plant-associated bacteria. Certain strains of the Pseudomonas syringae complex can further metabolize IAA into a less biologically active amino acid conjugate, 3-indole-acetyl-ε-L-lysine,...

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Nat. Commun. 6 , 6046, (2015)

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present results ...

Suitability of porcine chondrocyte micromass culture to model osteoarthritis in vitro.

Mol. Pharm. 11(7) , 2092-105, (2014)

In vitro tissue models are useful tools for the development of novel therapy strategies in cartilage repair and care. The limited availability of human primary tissue and high costs of animal models hamper preclinical tests of innovative substances and techni...

Osteoblast-specific overexpression of amphiregulin leads to transient increase in femoral cancellous bone mass in mice.

Bone 81 , 36-46, (2015)

The epidermal growth factor receptor ligand amphiregulin (AREG) has been implicated in bone physiology and in bone anabolism mediated by intermittent parathyroid hormone treatment. However, the functions of AREG in bone have been only incipiently evaluated in...

Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype.

Biomaterials 74 , 31-41, (2015)

Valvular interstitial cells (VICs) actively maintain and repair heart valve tissue; however, persistent activation of VICs to a myofibroblast phenotype can lead to aortic stenosis. To better understand and quantify how microenvironmental cues influence VIC ph...

An Exopolysaccharide-Deficient Mutant of Lactobacillus rhamnosus GG Efficiently Displays a Protective Llama Antibody Fragment against Rotavirus on Its Surface.

Appl. Environ. Microbiol. 81 , 5784-93, (2015)

Rotavirus is the leading cause of infantile diarrhea in developing countries, where it causes a high number of deaths among infants. Two vaccines are available, being highly effective in developed countries although markedly less efficient in developing count...

Persistent reduced oxygen requirement following blood transfusion during recovery from hemorrhagic shock.

Respir. Physiol. Neurobiol. 215 , 39-46, (2015)

Our study intended to determine the effects on oxygen uptake (VO2) of restoring a normal rate of O2 delivery following blood transfusion (BT) after a severe hemorrhage (H). Spontaneously breathing urethane anesthetized rats were bled by removing 20 ml/kg of b...

Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions.

BMC Genomics 15 , 787, (2014)

Burkholderia pseudomallei, the causative agent of melioidosis, is a Gram-negative bacterium widely distributed in soil and water in endemic areas. This soil saprophyte can survive harsh environmental conditions, even in soils where herbicides (containing supe...