1-Chloro-2-isocyanatoethane
1-Chloro-2-isocyanatoethane structure
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Common Name | 1-Chloro-2-isocyanatoethane | ||
|---|---|---|---|---|
| CAS Number | 1943-83-5 | Molecular Weight | 105.523 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 135.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C3H4ClNO | Melting Point | 135ºC | |
| MSDS | Chinese USA | Flash Point | 56.7±0.0 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Uniform small graphene oxide as an efficient cellular nanocarrier for immunostimulatory CpG oligonucleotides.
ACS Appl. Mater. Interfaces 6(10) , 7926-32, (2014) Graphene oxide (GO) has attracted more and more attention as a promising nanomaterial in biomedical research and applications. In this study, we explore the ability of GO as nanocarrier for synthetic DNA strands. Immunostimulatory CpG oligodeoxynucleotides (O... |
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Isocyanate binding to yeast glutathione reductase measured by fluorescence spectroscopy.
Biochem. Soc. Trans. 25(1) , 47S, (1997)
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Novel dynamic flow cytoenzymological determination of intracellular esterase inhibition by BCNU and related isocyanates.
Biochem. Pharmacol. 36(21) , 3731-8, (1987) We present a novel dynamic flow cytoenzymological demonstration of the potent inhibition by the antitumour chloroethylnitrosourea BCNU of the intracellular hydrolysis of fluorescein diacetate by esterases of viable, intact murine and human tumour cells in vit... |
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Biotransformation of carcinogenic arylamines and arylamides by human placenta.
J. Lab. Clin. Med. 124(1) , 134-41, (1994) Placental biotransformation reactions may modulate the effect a xenobiotic has on the developing fetus. However, in spite of the critical role the placenta plays in supporting fetal life, little is known about the pharmacology and toxicology of the human plac... |
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Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro.
Chem. Res. Toxicol. 6(3) , 376-83, (1993) The antitumor agent N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) is known to be unstable in aqueous solution, and to degrade spontaneously to reactive alkylating and carbamoylating intermediates. Whereas the alkylating component is believed to be responsible ... |
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1,3-Bis(2-chloroethyl)-1-nitrosourea as thiol-carbamoylating agent in biological systems.
Meth. Enzymol. 251 , 173, (1995)
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Microwave spectrum and conformational composition of 2-chloroethylisocyanide.
J. Phys. Chem. A 115(46) , 13474-81, (2011) 2-Chloroethylisocyanide (ClCH(2)CH(2)N≡C) has been synthesized, and its microwave spectrum has been investigated in the 20-97 GHz spectral region. The spectra of (35)Cl and (37)Cl isotopologues of two conformers have been assigned. The Cl-C-C-N chain of atoms... |
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Cloning and expression of a PKC-regulated chloride channel.
Jpn. J. Physiol. 44 Suppl 2 , S55-62, (1994) The cDNA of a protein kinase C-regulated chloride channel (CIC-3) was cloned. CIC-3 encodes 760 amino acids, which has significant amino acid identity with the previously cloned CIC chloride channels. CIC-3 cRNA elicited the chloride currents in Xenopus oocyt... |
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Measurement of carbamoylating activity of nitrosoureas and isocyanates by a novel high-pressure liquid chromatography assay.
Biochem. Pharmacol. 35(14) , 2359-65, (1986) A new assay for carbamoylating activity using reversed phase liquid chromatography (HPLC) is described which offers several advantages over existing assays. A comparison was made of the extent of carbamoylation of the amino group of 5'-amino-5'-deoxythymidine... |
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Inhibition of protein A24 lyase by nitrosoureas.
FEBS Lett. 176(2) , 426-30, (1984) The protein A24 content of Ehrlich ascites tumor cells increased several-fold following treatment of cell cultures with nitrosoureas, but did not increase when other alkylating agents not containing carbamoyl moieties were tested. The same nitrosoureas and, i... |