(S)-timolol maleate
(S)-timolol maleate structure
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Common Name | (S)-timolol maleate | ||
|---|---|---|---|---|
| CAS Number | 26921-17-5 | Molecular Weight | 432.492 | |
| Density | N/A | Boiling Point | 704.6ºC at 760 mmHg | |
| Molecular Formula | C17H28N4O7S | Melting Point | 202-203 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 380ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle.
J. Pharmacol. Exp. Ther. 350(3) , 681-90, (2014) We previously found a negative inotropic (NIR) and positive lusitropic response (LR) to C-type natriuretic peptide (CNP) in the failing heart ventricle. In this study, we investigated and compared the functional responses to the natriuretic peptides (NPs), br... |
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Dual drug delivery from vitamin E loaded contact lenses for glaucoma therapy.
Eur. J. Pharm. Biopharm. 94 , 312-21, (2015) Glaucoma patients frequently instill eye drops multiple times each day, which is a cause for reduced compliance. Additionally, eye drops suffer from other limitations including low bioavailability, which can lead to side effects. We propose to develop drug-el... |
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Author reply: To PMID 24576886.
Ophthalmology 121(12) , e68, (2014)
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Incidence and treatment of infantile haemangioma in preterm infants.
Arch. Dis. Child Fetal Neonatal Ed. 100(1) , F85-91, (2015) Infantile haemangioma (IH) are vascular tumours with a unique growth dynamic, mostly absent at birth, growth in the first months followed by involution over several years, often resulting in residual skin changes. Immune-histologically, IH cells are exclusive... |
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Development of a biomimetic phospholipid vesicle-based permeation assay for the estimation of intestinal drug permeability.
J. Pharm. Sci. 103(6) , 1882-90, (2014) Permeability is a crucial property of orally administered drugs. Therefore, in drug discovery, it is important to employ methods suitable for rapidly and reliably screening the permeability of large numbers of new drug candidates. The phospholipid vesicle-bas... |
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Effect of lyophilized grapefruit juice on P-glycoprotein-mediated drug transport in-vitro and in-vivo.
Drug Dev. Ind. Pharm. 41(3) , 375-81, (2015) The administration of grapefruit juice (GFJ) has been postulated to inhibit the activity of P-glycoprotein (P-gp) transport system and thus can enhance the uptake of substrate drugs. However, for various reasons, the results obtained have been always swaying ... |
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In vivo assessment of aqueous humor dynamics upon chronic ocular hypertension and hypotensive drug treatment using gadolinium-enhanced MRI.
Invest. Ophthalmol. Vis. Sci. 55(6) , 3747-57, (2014) Although glaucoma treatments alter aqueous humor (AH) dynamics to lower intraocular pressure, the regulatory mechanisms of AH circulation and their contributions to the pathogenesis of ocular hypertension and glaucoma remain unclear. We hypothesized that gado... |
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Evaluation of skin permeation of β-blockers for topical drug delivery.
Pharm. Res. 30(3) , 866-77, (2013) β-Blockers have recently become the main form of treatment of infantile hemangiomas. Due to the potential systemic adverse effects of β-blockers, topical skin treatment of the drugs is preferred. However, the effect and mechanism of dosage form pH upon skin p... |
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24-hour efficacy of the bimatoprost-timolol fixed combination versus latanoprost as first choice therapy in subjects with high-pressure exfoliation syndrome and glaucoma.
Br. J. Ophthalmol. 97(7) , 857-61, (2013) To compare the 24-h intraocular pressure (IOP) control obtained with the bimatoprost-timolol fixed combination (BTFC) versus latanoprost in newly diagnosed, previously untreated exfoliation syndrome (XFS) or exfoliative glaucoma (XFG) patients with baseline m... |
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Bimatoprost 0.03%/timolol 0.5% preservative-free ophthalmic solution versus bimatoprost 0.03%/timolol 0.5% ophthalmic solution (Ganfort) for glaucoma or ocular hypertension: a 12-week randomised controlled trial.
Br. J. Ophthalmol. 98(7) , 926-31, (2014) To compare the efficacy and safety of single-dose bimatoprost 0.03%/timolol 0.5% preservative-free (PF) ophthalmic solution with bimatoprost 0.03%/timolol 0.5% ophthalmic solution in patients with open-angle glaucoma or ocular hypertension.In this multicentre... |