Tibolone(Liviella)(Livial)
Tibolone(Liviella)(Livial) structure
|
Common Name | Tibolone(Liviella)(Livial) | ||
|---|---|---|---|---|
| CAS Number | 5630-53-5 | Molecular Weight | 312.446 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 447.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C21H28O2 | Melting Point | 169 °C | |
| MSDS | Chinese USA | Flash Point | 190.6±21.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Tibolone prevents oxidation and ameliorates cholinergic deficit induced by ozone exposure in the male rat hippocampus.
Neurochem. Res. 39(9) , 1776-86, (2014) Oxidative stress is related to the development of central nervous system diseases involving memory processes. Cholinergic system and memory processes are disrupted by ozone exposure. In rats, ozone induces motor disturbances and memory deficits as well as bio... |
|
|
Effects of tibolone or continuous combined oestradiol/norethisterone acetate on glucose and insulin metabolism.
Clin. Endocrinol. (Oxf.) 78(2) , 297-302, (2013) To determine the effects of tibolone or oestradiol (E(2) )/norethisterone acetate (NETA) hormone replacement therapy on glucose and insulin metabolism in postmenopausal women.Single-centre double-blind placebo-controlled randomized clinical trial.We randomize... |
|
|
Effects of a continuous-combined regimen of low-dose hormone therapy (oestradiol and norethindrone acetate) and tibolone on the quality of life in symptomatic postmenopausal women: a double-blind, randomised study.
Maturitas 74(2) , 172-8, (2013) This study compared the effects of a continuous-combined regimen of low-dose hormone therapy (LD-HT) versus tibolone and supplemental calcium/vitamin D3 (control) on quality of life (QoL) in symptomatic postmenopausal women.This study was a prospective, rando... |
|
|
Changes in the size of rectovaginal endometriotic nodules infiltrating the rectum during hormonal therapies.
Arch. Gynecol. Obstet. 287(3) , 447-53, (2013) To evaluate the changes in the volume of rectovaginal endometriotic nodules infiltrating the rectum during 12-month treatment with hormonal therapies.This prospective, non-randomized, self-controlled clinical trial included patients with rectovaginal endometr... |
|
|
Antioxidant effect of the active metabolites of tibolone.
Gynecol. Endocrinol. 31(1) , 31-5, (2014) Certain steroidal compounds have an antioxidant effect in humans. Our aim was to test whether the synthetic steroid tibolone and its metabolites are also able to display such a property. For this, granulocytes from healthy men and women were incubated for two... |
|
|
Changes in serum calcium and vitamin D₃ levels after tibolone treatment and their correlations with health-related quality of life.
Int. J. Gynaecol. Obstet. 128(2) , 174-6, (2015) To assess the effects of tibolone on serum calcium and vitamin D3 levels, the effects on health-related quality of life (HRQOL), and the relationship between these variables.An open-label, prospective, parallel-arm study was conducted at S.C. Das Memorial Med... |
|
|
Postmenopausal tibolone therapy: biologic principles and applied clinical practice.
MedGenMed 9(1) , 2, (2007) Although the menopause is a generic physiologic event, its biology is variable and specific to a given individual. Genetically determined distribution and polymorphism of relevant hormone receptors, enzymes, and various cofactors are the biologic mechanisms c... |
|
|
Therapeutic effects of progestins, androgens, and tibolone for menopausal symptoms.
Am. J. Med. 118 Suppl 12B , 88-92, (2005) Therapeutic strategies using progestins, androgens, and synthetic steroids such as tibolone are based on the understanding that estrogen, progesterone, and androgen receptors are localized to reproductive target tissues, brain, and bone. Unfortunately, these ... |
|
|
The effects of tibolone and oestrogen-based HT on breast cell proliferation and mammographic density.
Maturitas 49(1) , S16-21, (2004) Tibolone is a tissue-selective compound used for the treatment of climacteric symptoms and the prevention of osteoporosis in post-menopausal women. In this review some in vitro data and clinical studies indicating that the effects of tibolone on breast tissue... |
|
|
Updated clinical recommendations for the use of tibolone in Asian women.
Climacteric 13(4) , 317-27, (2010) Tibolone, which is indicated for the relief of climacteric symptoms and the prevention of osteoporosis in postmenopausal women, has a tissue-specific mode of action different to that of conventional hormone replacement therapy (HRT). A large proportion of Asi... |