Misoprostol
Misoprostol structure
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Common Name | Misoprostol | ||
|---|---|---|---|---|
| CAS Number | 59122-46-2 | Molecular Weight | 382.534 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 497.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C22H38O5 | Melting Point | 261-263°C | |
| MSDS | USA | Flash Point | 160.4±22.2 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Bleeding diathesis and gastro-duodenal ulcers in inherited cytosolic phospholipase-A2 alpha deficiency.
Thromb. Haemost. 112(6) , 1182-9, (2014) Arachidonic acid (AA), when cleaved from phospholipids by cytosolic phospholipase A2 alpha (cPLA2a), generates eicosanoids, with pro-hemostatic, pro-inflammatory, vasoactive and gastro-protective functions. We describe a patient (27-year-old man) and his twin... |
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Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats.
J. Pharmacol. Exp. Ther. 348(2) , 227-35, (2014) Antisecretory drugs such as histamine H₂-receptor antagonists and proton pump inhibitors are commonly used for the treatment of upper gastrointestinal mucosal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs). However, it has recently been repo... |
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Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy
Biochim. Biophys. Acta 1830(6) , 3776-86, (2013) Background The gastro-intestinal disorders, induced by the NSAIDs including indomethacin (IND) remain unresolved medical problems. Herein, we disclose allylpyrocatechol (APC) as a potential agent against IND-gastropathy and rationalize its action mechanistica... |
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Evolving therapeutic strategies to improve nonsteroidal anti-inflammatory drug safety.
Am. J. Ther. 22 , e167-78, (2015) Nonsteroidal anti-inflammatory drugs (NSAIDs) possess potent anti-inflammatory and analgesic properties through inhibition of cyclooxygenase enzymes (COX-1 and COX-2), which are responsible for synthesis of proinflammatory mediators. NSAIDs are frequently use... |
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Production of prostaglandin E2 induced by cigarette smoke modulates tissue factor expression and activity in endothelial cells.
FASEB J. 29 , 4001-10, (2015) Cigarette smoke (CS) increases the incidence of atherothrombosis, the release of prostaglandin (PG) E2, and the amount of tissue factor (TF). The link between PGE2 and TF, and the impact of this interaction on CS-induced thrombosis, is unknown. Plasma from ac... |
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PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice.
Neurobiol. Aging 36 , 1439-50, (2015) Intracerebral hemorrhage (ICH) is a devastating form of stroke. Misoprostol, a synthetic prostaglandin E1 (PGE1) analog and PGE2 receptor agonist, has shown protection against cerebral ischemia. In this study, we tested the efficacy of misoprostol in the 12-m... |
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Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.
Nat. Commun. 6 , 6956, (2015) Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen-host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted partic... |
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Sodium caprate-induced increases in intestinal permeability and epithelial damage are prevented by misoprostol.
Eur. J. Pharm. Biopharm. 94 , 194-206, (2015) Epithelial damage caused by intestinal permeation enhancers is a source of debate concerning safety. The medium chain fatty acid, sodium caprate (C10), causes reversible membrane perturbation at high dose levels required for efficacy in vivo, so the aim was t... |
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Sublingual misoprostol as an adjunct to oxytocin during cesarean delivery in women at risk of postpartum hemorrhage.
Int. J. Gynaecol. Obstet. 128(1) , 48-52, (2014) To evaluate whether a combination of misoprostol and oxytocin more effectively reduces blood loss during and after cesarean delivery than does oxytocin alone among women with known risk factors for postpartum hemorrhage (PPH).A prospective, randomized, double... |
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Sequential use of double-balloon catheter and oral misoprostol versus oral misoprostol alone for induction of labour at term (CRBplus trial): a multicentre, open-label randomised controlled trial.
BJOG 122(1) , 129-36, (2015) To evaluate the efficacy of inducing labour using a double-balloon catheter and oral misoprostol sequentially, in comparison with oral misoprostol alone.A multicentre randomised controlled trial.Five hospitals in Germany.A total of 326 pregnant women with an ... |