Medroxyprogesterone 17-acetate
Medroxyprogesterone 17-acetate structure
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Common Name | Medroxyprogesterone 17-acetate | ||
|---|---|---|---|---|
| CAS Number | 71-58-9 | Molecular Weight | 386.524 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 496.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C24H34O4 | Melting Point | 206-207 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 213.2±28.8 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
J. Med. Chem. 48 , 5666-74, (2005) We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular dynamics simulations, and linear-interaction energy analysis... |
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Immune status, strain background, and anatomic site of inoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas.
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Germ line knockout of IGFBP-3 reveals influences of the gene on mammary gland neoplasia.
Breast Cancer Res. Treat. 149(3) , 577-85, (2015) Insulin-like growth factor binding protein-3 (IGFBP-3) is an important carrier protein for insulin-like growth factors (IGFs) in the circulation. IGFBP-3 antagonizes the growth-promoting and anti-apoptotic activities of IGFs in experimental systems, but in ce... |
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PI3K/Akt-independent NOS/HO activation accounts for the facilitatory effect of nicotine on acetylcholine renal vasodilations: modulation by ovarian hormones.
PLoS ONE 9(4) , e95079, (2014) We investigated the effect of chronic nicotine on cholinergically-mediated renal vasodilations in female rats and its modulation by the nitric oxide synthase (NOS)/heme oxygenase (HO) pathways. Dose-vasodilatory response curves of acetylcholine (0.01-2.43 nmo... |
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FOXO1 is required for binding of PR on IRF4, novel transcriptional regulator of endometrial stromal decidualization.
Mol. Endocrinol. 29(3) , 421-33, (2015) The forkhead box O1A (FOXO1) is an early-induced target of the protein kinase A pathway during the decidualization of human endometrial stromal cells (HESCs). In this study we identified the cistrome and transcriptome of FOXO1 and its role as a transcriptiona... |
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The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy.
EMBO Mol. Med. 6(9) , 1161-74, (2014) Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post-partum haemorrhage. Uterine contractile patterns are controlled by the generation of complex electrical signals at th... |
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Highlights from the 21st CROI.
Lancet Infect. Dis. 14(4) , 276-7, (2014)
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