iCRT-14
iCRT-14 structure
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Common Name | iCRT-14 | ||
|---|---|---|---|---|
| CAS Number | 677331-12-3 | Molecular Weight | 375.44400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H17N3O2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis.
Nat. Commun. 5 , 5536, (2014) Animal evolution is closely linked to the emergence of the nervous system. At present it is unknown how the basic mechanisms of neural induction and formation of central nervous systems evolved. We addressed this question in Nematostella vectensis, a member o... |
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A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells.
Stem Cells 32(12) , 3196-208, (2014) Wnt/β-catenin signaling is essential for neurogenesis but less is known about β-catenin-independent Wnt signals. We show here that Wnt/activator protein-1 (AP-1) signaling drives differentiation of human embryonic stem cell and induced pluripotent stem cell-d... |
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Targeting Wnt pathway in mantle cell lymphoma-initiating cells.
J. Hematol. Oncol. 8 , 63, (2015) Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin's lymphoma. Despite initial intense chemotherapy, up to 50% of cases of MCL relapse often in a chemoresistant form. We hypothesized that the recently identified MCL-initiating cells... |
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Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia.
Br. J. Haematol. 167(1) , 87-99, (2014) While childhood acute lymphoblastic leukaemia (ALL) is now highly curable, the dismal prognosis for children who relapse warrants novel therapeutic approaches. Previously, using an integrated genomic analysis of matched diagnosis-relapse paired samples, we id... |
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An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.
Proc. Natl. Acad. Sci. U. S. A. 108 , 5954-5963, (2011) Misregulated β-catenin responsive transcription (CRT) has been implicated in the genesis of various malignancies, including colorectal carcinomas, and it is a key therapeutic target in combating various cancers. Despite significant effort, successful clinical... |
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Winning WNT: race to Wnt signaling inhibitors.
Proc. Natl. Acad. Sci. U. S. A. 108(15) , 5929-30, (2011)
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Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors.
J. Clin. Invest. 124(7) , 3061-74, (2014) Ewing's sarcoma is a highly malignant bone tumor found in children and adolescents, and the origin of this malignancy is not well understood. Here, we introduced a Ewing's sarcoma-associated genetic fusion of the genes encoding the RNA-binding protein EWS and... |
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LIG4 mediates Wnt signalling-induced radioresistance.
Nat. Commun. 7 , 10994, (2016) Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs). We find that LIG4,... |
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PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness.
Nat. Commun. 7 , 10633, (2016) Cancer stem cells (CSCs) contribute to tumour heterogeneity, therapy resistance and metastasis. However, the regulatory mechanisms of cancer cell stemness remain elusive. Here we identify PCNA-associated factor (PAF) as a key molecule that controls cancer cel... |