Pyrolin
Pyrolin structure
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Common Name | Pyrolin | ||
|---|---|---|---|---|
| CAS Number | 95-71-6 | Molecular Weight | 124.137 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 277.8±20.0 °C at 760 mmHg | |
| Molecular Formula | C7H8O2 | Melting Point | 125-128ºC | |
| MSDS | Chinese USA | Flash Point | 140.2±16.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Altering toluene 4-monooxygenase by active-site engineering for the synthesis of 3-methoxycatechol, methoxyhydroquinone, and methylhydroquinone.
J. Bacteriol. 186(14) , 4705-13, (2004) Wild-type toluene 4-monooxygenase (T4MO) of Pseudomonas mendocina KR1 oxidizes toluene to p-cresol (96%) and oxidizes benzene sequentially to phenol, to catechol, and to 1,2,3-trihydroxybenzene. In this study T4MO was found to oxidize o-cresol to 3-methylcate... |
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Toluquinol, a marine fungus metabolite, is a new angiosuppresor that interferes with the Akt pathway.
Biochem. Pharmacol. 85(12) , 1727-40, (2013) Toluquinol, a methylhydroquinone produced by a marine fungus, was selected in the course of a blind screening for new potential inhibitors of angiogenesis. In the present study we provide the first evidence that toluquinol is a new anti-angiogenic-compound. I... |
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Possible tumor-initiating and -promoting activity of p-methylcatechol and methylhydroquinone in the pyloric mucosa of rat stomach.
Jpn. J. Cancer Res. 84(3) , 223-9, (1993) The possible tumor-promoting and tumor-initiating activities of p-methylcatechol and methylhydroquinone in the pyloric mucosa of male F344 rats were studied. Ornithine decarboxylase (ODC) and replicative DNA synthesis (RDS) were used as markers of tumor promo... |
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Protein engineering of toluene-o-xylene monooxygenase from Pseudomonas stutzeri OX1 for synthesizing 4-methylresorcinol, methylhydroquinone, and pyrogallol.
Appl. Environ. Microbiol. 70(6) , 3253-62, (2004) Toluene-o-xylene monooxygenase (ToMO) from Pseudomonas stutzeri OX1 oxidizes toluene to 3- and 4-methylcatechol and oxidizes benzene to form phenol; in this study ToMO was found to also form catechol and 1,2,3-trihydroxybenzene (1,2,3-THB) from phenol. To syn... |
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Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis.
Mol. Microbiol. 67(5) , 1108-24, (2008) Recently, we showed that the MarR-type repressor YkvE (MhqR) regulates multiple dioxygenases/glyoxalases, oxidoreductases and the azoreductase encoding yvaB (azoR2) gene in response to thiol-specific stress conditions, such as diamide, catechol and 2-methylhy... |
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The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis.
Mol. Microbiol. 66(1) , 40-54, (2007) Catechol and 2-methylhydroquinone (2-MHQ) cause the induction of the thiol-specific stress response and four dioxygenases/glyoxalases in Bacillus subtilis. Using transcription factor arrays, the MarR-type regulator YkvE was identified as a repressor of the di... |
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Nitric oxide promotes strong cytotoxicity of phenolic compounds against Escherichia coli: the influence of antioxidant defenses.
Free Radic. Biol. Med. 35(11) , 1373-81, (2003) The induction of mutagenic and cytotoxic effects by simple phenolics, including catechol (CAT), 3,4-dihydroxyphenylacetic acid (DOPAC), hydroquinone (HQ), and 2,5-dihydroxyphenylacetic (homogentisic) acid (HGA), appears to occur through an oxidative mechanism... |
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Oxidative DNA damage by minor metabolites of toluene may lead to carcinogenesis and reproductive dysfunction.
Biochem. Biophys. Res. Commun. 261(2) , 478-83, (1999) Recently, the concern that toluene might have carcinogenic and reproductive toxic potential has been raised. We investigated the ability of DNA damage by minor metabolites of toluene, methylhydroquinone, and methylbenzoquinone, using (32)P-5'-end-labeled DNA ... |
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Lipoxygenase-inhibitory action of antiviral polymeric oxidation products of polyphenols.
Biomed. Biochim. Acta 50(3) , 299-305, (1991) Various polymeric oxidation products of polyphenols strongly inhibited the purified lipoxygenase of rabbit reticulocytes, whereas the prostaglandin H synthase of sheep vesicular gland was only weakly inhibited. The oxidized polymeric preparations of caffeic a... |
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Patulin biosynthesis: epoxidation of toluquinol and gentisyl alcohol by particulate preparations from Penicillium patulum.
Biochemistry 28(23) , 9192-200, (1989) A crude extract that catalyzes the epoxidation of toluquinol and gentisyl alcohol was isolated from cultures of Penicillium patulum. About 60% of the activity sedimented from crude extract upon centrifugation at 105,000g for 2 h, and at 30,000g for 30 min aft... |