Clofazimine
Clofazimine structure
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Common Name | Clofazimine | ||
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| CAS Number | 2030-63-9 | Molecular Weight | 473.396 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 566.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C27H22Cl2N4 | Melting Point | 210-212° | |
| MSDS | Chinese USA | Flash Point | 296.7±30.1 °C | |
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The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.
Antimicrob. Agents Chemother. 59(3) , 1534-41, (2015) Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase the potency of antituberculosis (anti-TB) drugs against Mycob... |
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Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis.
Proc. Natl. Acad. Sci. U. S. A. 112(3) , 869-74, (2015) A key drug for the treatment of leprosy, clofazimine has recently been associated with highly effective and significantly shortened regimens for the treatment of multidrug-resistant tuberculosis (TB). Consequently, we hypothesized that clofazimine may also sh... |
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Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co-formulation.
Drug Deliv Transl Res 5 , 257-67, (2015) Contemporary chemotherapy is limited by disseminated, resistant cancer. Targeting nanoparticulate drug delivery systems that encapsulate synergistic drug combinations are a rational means to increase the therapeutic index of chemotherapeutics. A lipopolymeric... |
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Clofazimine Induced Suicidal Death of Human Erythrocytes.
Cell Physiol. Biochem. 37 , 331-41, (2015) The antimycobacterial riminophenazine clofazimine has previously been shown to up-regulate cellular phospholipase A2 and to induce apoptosis. In erythrocytes phospholipase A2 stimulates eryptosis, the suicidal erythrocyte death characterized by cell shrinkage... |
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State-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine.
Br. J. Pharmacol. 172 , 5161-73, (2015) Kv 1.3 potassium channels are promising pharmaceutical targets for treating immune diseases as they modulate Ca(2+) signalling in T cells by regulating the membrane potential and with it the driving force for Ca(2+) influx. The antimycobacterial drug clofazim... |
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Bone distribution study of anti leprotic drug clofazimine in rat bone marrow cells by a sensitive reverse phase liquid chromatography method.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 960 , 82-6, (2014) The aim of the present study was to investigate the distribution of clofazimine (CLF) in rat bone marrow cells by a validated reverse phase high performance liquid chromatography. CLF and chlorzoxazone (I.S) were extracted by liquid-liquid extraction from pla... |
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OFLOXACIN multicentre trial in MB leprosy FUAM-Manaus and ILSL-Bauru, Brazil.
Lepr. Rev. 83(3) , 261-8, (2012) Recently antimicrobials of the fluoroquinolone class (pefloxacin and ofloxacin) were found far more effective against Mycobacterium leprae in studies with both mice and patients than dapsone and clofazimine. As multicentre trial participants, we evaluated the... |
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Developing new MDT regimens for MB patients; time to test ROM 12 month regimens globally.
Lepr. Rev. 83(3) , 241-4, (2012)
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Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Biol. Pharm. Bull. 38 , 1425-9, (2015) The direct inhibitory potential of twenty five anti-tuberculosis drugs on eight CYP-specific reactions in human liver microsomes was investigated to predict in vivo drug-drug interactions (DDIs) from in vitro data. Rifampicin, rifabutin, and thioacetazone inh... |
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Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs.
J. Infect. Dis. 210(3) , 456-66, (2014) Drug tolerance likely represents an important barrier to tuberculosis treatment shortening. We previously implicated the Mycobacterium tuberculosis efflux pump Rv1258c as mediating macrophage-induced tolerance to rifampicin and intracellular growth. In this s... |