Clofazimine

Modify Date: 2024-01-02 20:24:25

Clofazimine Structure
Clofazimine structure
 Common Name Clofazimine
CAS Number 2030-63-9 Molecular Weight 473.396
Density 1.3±0.1 g/cm3 Boiling Point 566.9±50.0 °C at 760 mmHg
Molecular Formula C27H22Cl2N4 Melting Point 210-212°
MSDS Chinese USA Flash Point 296.7±30.1 °C

 Use of Clofazimine


Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.

 Names

Name clofazimine
Synonym More Synonyms

 Clofazimine Biological Activity

Description Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.
Related Catalog

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 566.9±50.0 °C at 760 mmHg
Melting Point 210-212°
Molecular Formula C27H22Cl2N4
Molecular Weight 473.396
Flash Point 296.7±30.1 °C
Exact Mass 472.122162
PSA 42.21000
LogP 7.26
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.667
Water Solubility Practically insoluble in water, soluble in methylene chloride, very slightly soluble in ethanol (96 per cent). It shows polymorphism (5.9).

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SG1578000
CHEMICAL NAME :
Phenazine, 2,10-dihydro-3-(p-chloroanilino)-10-(p-chlorophenyl)- 2-(isopropylimino)-
CAS REGISTRY NUMBER :
2030-63-9
BEILSTEIN REFERENCE NO. :
0060420
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C27-H22-Cl2-N4
MOLECULAR WEIGHT :
473.43
WISWESSER LINE NOTATION :
T C666 BN IN EHJ BR DG& ENUY1&1 FMR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
4400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 32,911,1994

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS SG1578000
HS Code 35040000

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles54

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The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.

Antimicrob. Agents Chemother. 59(3) , 1534-41, (2015)

Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase th...
Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis.

Proc. Natl. Acad. Sci. U. S. A. 112(3) , 869-74, (2015)

A key drug for the treatment of leprosy, clofazimine has recently been associated with highly effective and significantly shortened regimens for the treatment of multidrug-resistant tuberculosis (TB)....
Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co-formulation.

Drug Deliv Transl Res 5 , 257-67, (2015)

Contemporary chemotherapy is limited by disseminated, resistant cancer. Targeting nanoparticulate drug delivery systems that encapsulate synergistic drug combinations are a rational means to increase ...

 Synonyms

2-Phenazinamine, N,5-bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-
N,5-Bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydro-2-phenazinamine
Clofaziminum [INN-Latin]
2-Phenazinamine, N,5-bis(4-chlorophenyl)-3,5-dihydro-3-((1-methylethyl)imino)-
Clofazimine
Clofaziminum
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
Chlofazimine
Clofazimine (N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
Clofazimina [INN-Spanish]
Lamprene
Lampren
2-(4-chloro-anilino)-5-(4-chloro-phenyl)-3-isopropylamino-phenazinium-betaine
2-(4-Chlor-anilino)-5-(4-chlor-phenyl)-3-isopropylamino-phenazinium-betain
B 663 (Pharmaceutical)
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
Clofazimina
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Related Compounds: More...
Clofazimine nitrate
352464-74-5
Clofazimine Related Compound 1
90690-85-0
Chemsrc provides Clofazimine(CAS#:2030-63-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Clofazimine are included as well.>> amp version: Clofazimine

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