Microcystin-LR
Microcystin-LR structure
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Common Name | Microcystin-LR | ||
|---|---|---|---|---|
| CAS Number | 101043-37-2 | Molecular Weight | 995.172 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C49H74N10O12 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 11 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Growth inhibition and microcystin degradation effects of Acinetobacter guillouiae A2 on Microcystis aeruginosa.
Res. Microbiol. 166(2) , 93-101, (2015) Strain A2 with algicidal activity against Microcystis aeruginosa was isolated and identified with the genus Acinetobacter on the basis of phenotypic tests and 16S rRNA gene analysis. It was identified with the species Acinetobactor guillouiae by partial rpoB ... |
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Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets.
J. Thromb. Haemost. 12(5) , 748-60, (2014) Rapamycin, an inhibitor of mammalian target of rapamycin complex-1 (mTORC1), reduces platelet spreading, thrombus stability, and clot retraction. Despite an important role of mTORC1 in platelet function, little is known about how it is regulated. The objectiv... |
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Sensitive detection of microcystin-LR by using a label-free electrochemical immunosensor based on Au nanoparticles/silicon template/methylene blue nanocomposite.
J. Nanosci. Nanotechnol. 13(12) , 8245-52, (2013) A label-free electrochemical immunosensor, based on a gold nanoparticles (Au NPs)/silicon template/methylene blue (MB)/chitosan (CHIT) nanocomposite-modified electrode, was fabricated for the ultrasensitive detection of microcystin-LR (MC-LR). The nanocomposi... |
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Evidence for fibroblast growth factor-2 as a mediator of amphetamine-enhanced motor improvement following stroke.
PLoS ONE 9(9) , e108031, (2014) Previously we have shown that addition of amphetamine to physical therapy results in enhanced motor improvement following stroke in rats, which was associated with the formation of new motor pathways from cortical projection neurons of the contralesional cort... |
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The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos.
Aquat. Toxicol. 149 , 25-32, (2014) We previously demonstrated that cyanobacteria-derived microcystin-leucine-arginine (MCLR) is able to induce developing toxicity, such as malformation, growth delay and also decreased heart rates in zebrafish embryos. However, the molecular mechanisms by which... |
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Cellular transport of microcystin-LR in rainbow trout (Oncorhynchus mykiss) across the intestinal wall: possible involvement of multidrug resistance-associated proteins.
Aquat. Toxicol. 154 , 97-106, (2014) We studied Abcc mediated-transport in middle and posterior intestine of the rainbow trout, Oncorhynchus mykiss. Luminal and serosal transport were evaluated in everted and non-everted intestinal sacs, respectively, incubated with 1-chloro-2,4-dinitrobenzene (... |
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PP2A delays APC/C-dependent degradation of separase-associated but not free securin.
EMBO J. 33(10) , 1134-47, (2014) The universal triggering event of eukaryotic chromosome segregation is cleavage of centromeric cohesin by separase. Prior to anaphase, most separase is kept inactive by association with securin. Protein phosphatase 2A (PP2A) constitutes another binding partne... |
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Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling.
J. Clin. Invest. 118 , 1074-1075, (2008) Leukocytes from individuals with warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a rare immunodeficiency, and bearing a wild-type CXCR4 ORF (WHIM(WT)) display impaired CXCR4 internalization and desensitization upon exposure to CXC... |
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Damage and recovery of the ovary in female zebrafish i.p.-injected with MC-LR.
Aquat. Toxicol. 155 , 110-8, (2014) Up to now, in vivo studies on toxic effects of microcystins (MCs) on the reproductive system are limited and the underlying molecular mechanisms of MCs-induced reproductive toxicity remain to be elucidated. In an acute toxic experiment, female zebrafish (Dani... |
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Microcystin-LR induces anoikis resistance to the hepatocyte uptake transporter OATP1B3-expressing cell lines.
Toxicology 326 , 53-61, (2014) Microcystin-LR is a cyclic peptide released by several bloom-forming cyanobacteria. Understanding the mechanism of microcystin-LR toxicity is important, because of the both potencies of its acute cytotoxicity and tumor-promoting activity in hepatocytes of ani... |