Quinacrine (dihydrochloride)
Quinacrine (dihydrochloride) structure
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Common Name | Quinacrine (dihydrochloride) | ||
|---|---|---|---|---|
| CAS Number | 69-05-6 | Molecular Weight | 472.88 | |
| Density | 1.2962 (rough estimate) | Boiling Point | N/A | |
| Molecular Formula | C23H32Cl3N3O | Melting Point | ca. 248 - 250ºC (decomposes) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces.
J. Biomed. Mater. Res. A 103(4) , 1303-11, (2015) Although the thrombogenic nature of the surfaces of cardiovascular devices is an important aspect of blood biocompatibility, few studies have examined platelet deposition onto opaque materials used for these devices in real time. This is particularly true for... |
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Autophagic flux inhibition and lysosomogenesis ensuing cellular capture and retention of the cationic drug quinacrine in murine models.
PeerJ 3 , e1314, (2015) The proton pump vacuolar (V)-ATPase is the driving force that mediates the concentration of cationic drugs (weak bases) in the late endosome-lysosome continuum; secondary cell reactions include the protracted transformation of enlarged vacuoles into autophago... |
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Granule-mediated release of sphingosine-1-phosphate by activated platelets.
Biochim. Biophys. Acta 1841(11) , 1581-9, (2014) Sphingosine-1-phosphate (S1P) is an intracellularly generated bioactive lipid essential for development, vascular integrity, and immunity. These functions are mediated by S1P-selective cell surface G-protein coupled receptors. S1P signaling therefore requires... |
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Bone Marrow-Derived Mesenchymal Stem Cells Have Innate Procoagulant Activity and Cause Microvascular Obstruction Following Intracoronary Delivery: Amelioration by Antithrombin Therapy.
Stem Cells 33 , 2726-37, (2015) Mesenchymal stem cells (MSCs) are currently under investigation as tools to preserve cardiac structure and function following acute myocardial infarction (AMI). However, concerns have emerged regarding safety of acute intracoronary (IC) MSC delivery. This stu... |
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Prion protein-coated magnetic beads: synthesis, characterization and development of a new ligands screening method.
J. Chromatogr. A. 1379 , 1-8, (2015) Prion diseases are characterized by protein aggregation and neurodegeneration. Conversion of the native prion protein (PrP(C)) into the abnormal scrapie PrP isoform (PrP(Sc)), which undergoes aggregation and can eventually form amyloid fibrils, is a critical ... |
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Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Biol. Pharm. Bull. 35(12) , 2243-6, (2012) The present study was designed to clarify whether the arachidonic acid cascade contributes to the decreased threshold for pentylenetetrazole-induced seizure under benzodiazepine withdrawal in mice. The seizure threshold for pentylenetetrazole was significantl... |
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Identification of a small molecule that modifies MglA/SspA interaction and impairs intramacrophage survival of Francisella tularensis.
PLoS ONE 8(1) , e54498, (2013) The transcription factors MglA and SspA of Francisella tularensis form a heterodimer complex and interact with the RNA polymerase to regulate the expression of the Francisella pathogenicity island (FPI) genes. These genes are essential for this pathogen's vir... |
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Inhibition of influenza virus replication by targeting broad host cell pathways.
PLoS ONE 9(10) , e110631, (2014) Antivirals that are currently used to treat influenza virus infections target components of the virus which can mutate rapidly. Consequently, there has been an increase in the number of resistant strains to one or many antivirals in recent years. Here we comp... |