7-METHOXY-2-NITRONAPHTHO(2,1-b)FURAN
7-METHOXY-2-NITRONAPHTHO(2,1-b)FURAN structure
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Common Name | 7-METHOXY-2-NITRONAPHTHO(2,1-b)FURAN | ||
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| CAS Number | 75965-74-1 | Molecular Weight | 243.21500 | |
| Density | 1.379g/cm3 | Boiling Point | 420ºC at 760 mmHg | |
| Molecular Formula | C13H9NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 207.8ºC | |
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Genotoxicity of 2-nitro-7-methoxy-naphtho[2,1-b]furan (R7000): a case study with some considerations on nitrofurantoin and nifuroxazide.
Res. Microbiol. 153(7) , 427-34, (2002) Two nitrofurans present broad-spectrum antimicrobial properties and some of them are used in human and veterinary medicine. Most of these molecules are mutagens and some of them were reported as carcinogens. Due to its extreme mutagenic potency in bacteria, t... |
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First characterization of the mutagenic specificity of 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000) in Salmonella typhimurium.
Mutat. Res. 248(1) , 85-92, (1991) In order to investigate the mutational events induced by the very potent genotoxic agent 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), we evaluated its mutagenic potency in a battery of his- mutants of Salmonella typhimurium designed to study mutagenic specif... |
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Influence of the uvr-dependent nucleotide excision repair on DNA adducts formation and mutagenic spectrum of a potent genotoxic agent: 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000).
Mutat. Res. 358(1) , 113-22, (1996) The influence of the uvr-dependent excision repair system on the lethal action, mutagenic specificity, SOS induction and DNA adducts formation of 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), a potent genotoxic nitrofuran, were examined in Escherichia coli. B... |
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Mutagenic properties of a nitrofuran, 7-methoxy-2-nitronaphtho[2, 1-b]furan (R7000), in lacI transgenic mice.
Mutat. Res. 470(2) , 177-88, (2000) The in vivo mutagenic properties of a 5-nitrofuran, the 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), already well known in bacteria, was evaluated in lacI transgenic mice (Big Blue). The mutation frequency was determined in various organs of i.p. - treated m... |
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DNA damage induced in vivo by 7-methoxy-2-nitronaphtho[2,1-b]-furan (R7000) in the lacI gene of Escherichia coli.
Mutat. Res. 422(2) , 237-45, (1998) DNA adducts that block replication, induced in vivo by the 5-nitrofuran derivative R7000 (7-methoxy-2-nitronaphtho[2, 1-b]-furan) were mapped, at nucleotide resolution, in a region of the lacI gene of Escherichia coli, using a reiterative primer extension ass... |
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Comparison of the carcinogenic effects of two 2-nitro-naphthofurans injected sub-cutaneously in rats.
Cancer Lett. 35(1) , 59-64, (1987) 7-Methoxy-2-nitro-naphtho[2,1-b]furan (R 7000) and its methylated homolog in position 1 (R 7372) are among the most mutagenic agents presently known, as shown by the results obtained both in the Ames test and in the SOS Chromotest. Their carcinogenic effects ... |
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Global response of Escherichia coli cells to a treatment with 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), an extremely potent mutagen.
Mutat. Res. 349(2) , 193-200, (1996) We have studied the global changes which are induced in exponentially growing cultures of Escherichia coli during treatment with 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), a very potent mutagen and inducer of the SOS response. A two-dimensional analysis of... |
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In-vivo carcinogenicity of 2-nitro-oxaphenalenes.
Carcinogenesis 10(5) , 803-5, (1989) 2-Nitro-oxaphenalenes are synthetic chemicals which were synthesized in the authors' laboratory. They are the most efficient mutagenic compounds on mammalian cells in culture. They are chemically related to the nitro-naphthofuran family by the displacement of... |
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High recurrence of rearrangements involving chromosome 14 in an ataxia telangiectasia lymphoblastoid cell line and in its mutagen-treated derivatives.
Hum. Genet. 86(5) , 475-80, (1991) The cytogenetic characterization of CH cell line obtained by Epstein-Barr-virus transformation of the lymphocytes of a patient affected by ataxia telangiectasia is reported. Control CH cells and 2 subcultures treated with the mutagens R7000 or NQO were develo... |
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Lack of promoting activity of 7-methoxy-2-nitro-naphtho-[2,1-b]furan (R7000) in a medium-term rat liver bioassay.
Cancer Lett. 76(2-3) , 161-6, (1994) Among the nitro-naphthofurans, 7-methoxy-2-nitro-naphtho[2,1-b]furan (R7000) has proved to be a very potent mutagen that causes sarcomas at the subcutaneous injection site and carcinomas in the forestomach after p.o. administration. In the present study, poss... |