[Hyp<sup>3</sup>]Bradykinin
![[Hyp<sup>3</sup>]Bradykinin Structure](https://image.chemsrc.com/caspic/001/37642-65-2.png)
[Hyp<sup>3</sup>]Bradykinin structure
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Common Name | [Hyp<sup>3</sup>]Bradykinin | ||
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| CAS Number | 37642-65-2 | Molecular Weight | 1076.208 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C50H73N15O12 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Bradykinin receptors and their antagonists.
Eur. J. Pharmacol. 348 , 1-10, (1998) Bradykinin and related kinins act on two receptor types, named B1 and B2. Initially identified in classical bioassays, these receptors have been cloned and characterized in binding assays performed on plasma membranes of cells expressing the native or the tra... |
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Bradykinin receptor types and B2 subtypes.
Life Sci. 55 , 735-749, (1994) Bradykinin, desArg9BK, some agonist analogues and several antagonists have been tested in isolated organs in order to identify bradykinin B2 receptor subtypes. The initial pharmacological characterization was made in the rabbit jugular vein and the guinea pig... |
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Isolation and identification of hydroxyproline analogues of bradykinin in human urine.
FEBS Lett. 232 , 252, (1988) Hydroxyproline (Hyp) analogues of bradykinin and lysyl-bradykinin, in which the third residue of bradykinin, proline, is replaced by hydroxyproline, were isolated from human urine. Their amino acid sequences were confirmed by both amino acid and sequence anal... |
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[Hyp3]-bradykinin and [Hyp3]-Lys-bradykinin interact with B2-bradykinin receptors and stimulate inositol phosphate production in cultured human fibroblasts.
FEBS Lett. 262 , 111-114, (1990) The recently isolated, naturally occurring peptide hormones [Hyp3]-bradykinin and [Hyp3]-Lys-bradykinin were investigated for their agonist activity on solubilized binding sites from human fibroblasts. Both ligands competed with [3H]bradykinin binding in a do... |
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[Structures and functions of kininogen and kinin hydroxyproline derivatives as multi-functional proteins].
Rinsho. Ketsueki. 30(10) , 1690-3, (1989)
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Hydroxylated kininogens and kinins.
Agents Actions. Suppl. 38 ( Pt 1) , 217-24, (1992) Hydroxyprolyl-3-bradykinin was identified in the digest of purified human high molecular weight (H) kininogen with plasma kallikrein. Hydroxyproline was not detected in the heavy and light chains portions of H kininogen, although they include three possible s... |
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Potentiation by ACE inhibitors of the dilator response to bradykinin in the coronary microcirculation: interaction at the receptor level.
Br. J. Pharmacol. 111(1) , 238-44, (1994) 1. To examine the possibility that angiotensin-converting enzyme (ACE) inhibitors modulate the action of bradykinin at the receptor level, their effect on the dilator response to bradykinin was studied in the isolated saline-perfused heart of the rabbit. 2. C... |
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Degradation pathway of kinins in tumor ascites and inhibition by kininase inhibitors: analysis by HPLC.
Agents Actions 29(3-4) , 172-80, (1990) We have recently found presence of a high concentration of a novel type of kinin, hydroxyprolyl3-bradykinin (Hyp3-BK) in human tumor ascites in addition to conventional bradykinin (BK). Because of their potential physiological activity, it is of interest to k... |
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Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer.
J. Biol. Chem. 263(31) , 16051-4, (1988) Kinins in the ascitic fluid from a patient with gastric cancer were purified by gel filtration and reversed-phase high-performance liquid chromatography (HPLC). Two fractions (fractions I and II) showed kinin activity. Fraction I did not correspond to either ... |
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Hydroxyprolyl3-bradykinin in high molecular mass kininogen. Presence in human and monkey kininogens, but not in kininogens from bovine, rat, rabbit, guinea pig and mouse plasmas.
FEBS Lett. 238(1) , 1-4, (1988) The contents of hydroxyprolyl3-bradykinin in high molecular mass (HMM) kininogens from human and animal plasmas were examined by reversed-phase HPLC following their proteolytic scission by bovine plasma kallikrein. The relative contents of hydroxyprolyl3-brad... |