Agents and actions. Supplements 1992-01-01

Hydroxylated kininogens and kinins.

H Kato, K Enjyoji

Index: Agents Actions. Suppl. 38 ( Pt 1) , 217-24, (1992)

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Abstract

Hydroxyprolyl-3-bradykinin was identified in the digest of purified human high molecular weight (H) kininogen with plasma kallikrein. Hydroxyproline was not detected in the heavy and light chains portions of H kininogen, although they include three possible sites for hydroxylation of proline by proline hydroxylase. The content of hydroxyprolyl-3-bradykinin in H kininogen from individual plasmas varied from 14% to 64% of total kinin. The present results and our previous results indicate that only kinin moity in H kininogen from human and monkey plasmas has been partially hydroxylated post-translationally by proline-4-hydroxylase.