Dihydrouracil
Dihydrouracil structure
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Common Name | Dihydrouracil | ||
|---|---|---|---|---|
| CAS Number | 504-07-4 | Molecular Weight | 114.103 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 337.0±25.0 °C at 760 mmHg | |
| Molecular Formula | C4H6N2O2 | Melting Point | 279-281 °C(lit.) | |
| MSDS | N/A | Flash Point | 208.5±12.4 °C | |
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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.
Nature 457(7231) , 910-4, (2009) Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion an... |
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Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.
Kidney Int. 79(11) , 1244-53, (2011) Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (... |
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Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands.
Nucleic Acids Res. 42(10) , 6300-13, (2014) The human thymine-DNA glycosylase (TDG) initiates the base excision repair (BER) pathway to remove spontaneous and induced DNA base damage. It was first biochemically characterized for its ability to remove T mispaired with G in CpG context. TDG is involved i... |
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New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?
Biochem. J. 379(Pt 1) , 119-24, (2004) DPD (dihydropyrimidine dehydrogenase) constitutes the first step of the pyrimidine degradation pathway, in which the pyrimidine bases uracil and thymine are catabolized to beta-alanine and the R-enantiomer of beta-AIB (beta-aminoisobutyric acid) respectively.... |
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Automated screening system for purine and pyrimidine metabolism disorders using high-performance liquid chromatography.
J. Chromatogr. B, Biomed. Appl. 672(2) , 233-9, (1995) An automated screening system for purine and pyrimidine metabolism disorders using high-performance liquid chromatography (HPLC) with column switching is described. The system consists of a reversed-phase column, a cation-exchange column, a column switch, fou... |
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beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities.
Hum. Mol. Genet. 13(22) , 2793-801, (2004) beta-Ureidopropionase deficiency is an inborn error of the pyrimidine degradation pathway, affecting the cleavage of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyric acid. In this study, we report the elucidation of the genetic basis underlying a b... |
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Evidence for endogenous formation of the hepatocarcinogen N-nitrosodihydrouracil in rats treated with dihydrouracil and sodium nitrite: a potential source of human hepatic DNA carboxyethylation.
Chem. Biol. Interact. 206(1) , 83-9, (2013) An earlier study demonstrated that hydrolysates of all human liver DNA samples analyzed contain the DNA adduct 7-(2'-carboxyethyl)guanine (7-CEGua) with an average level of 74.6 adducts per 10(9) nucleotides. One possible source of this DNA adduct would be en... |
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Fasting serum free fatty acid composition, waist/hip ratio and insulin activity in essential hypertensive patients.
Hypertens. Res. 31(4) , 623-32, (2008) Abnormal fatty acid metabolism may play an important role in the pathogenesis of essential hypertension (EH). We compared fasting serum free fatty acid (FFA) composition between EH patients and nonhypertensive (NH) subjects, and examined the relationships bet... |
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Analysis of biogenic amines in plasma of hypertensive patients and a control group.
Neurochem. Res. 18(11) , 1179-82, (1993) Procedures were developed for the determination of 17 circulating amines using gas chromatography-negative ion chemical ionisation mass spectrometry. The amines were quantified against their appropriate deuterated isotopomers. The mean concentrations and rang... |
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Urinary tetrahydroaldosterone as a screening method for primary aldosteronism: a comparative study.
Am. J. Hypertens. 16(7) , 522-30, (2003) The major aldosterone metabolite 3 alpha,5 beta tetrahydroaldosterone reflects up to 45% of the aldosterone secretion. Its 24-h urinary excretion is likely to provide an accurate index of the daily aldosterone production and to be an indicator for primary ald... |