SIS3
SIS3 structure
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Common Name | SIS3 | ||
|---|---|---|---|---|
| CAS Number | 521984-48-5 | Molecular Weight | 489.993 | |
| Density | N/A | Boiling Point | 737.2ºC at 760 mmHg | |
| Molecular Formula | C28H28ClN3O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 399.7ºC | |
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AS101 prevents diabetic nephropathy progression and mesangial cell dysfunction: regulation of the AKT downstream pathway.
PLoS ONE 9(12) , e114287, (2014) Diabetic nephropathy (DN) is characterized by proliferation of mesangial cells, mesangial expansion, hypertrophy and extracellular matrix accumulation. Previous data have cross-linked PKB (AKT) to TGFβ induced matrix modulation. The non-toxic compound AS101 h... |
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Cyclosporine A induces connective tissue growth factor expression in human gingival fibroblasts: suppression by epigallocatechin-3-gallate.
J. Formos. Med. Assoc. 113(11) , 828-32, (2014) Transforming growth factor-β (TGF-β) plays an important role in the pathogenesis of cyclosporine A (CsA)-induced gingival overgrowth (GO). Connective tissue growth factor (CTGF/CCN2) acts as a cofactor with TGF-β to induce the maximal profibrotic effects of T... |
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Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1.
Arthritis. Res. Ther. 16(2) , R86, (2014) Although the pathogenesis of systemic sclerosis (SSc) still remains unknown, recent studies have demonstrated that endothelins are deeply involved in the developmental process of fibrosis and vasculopathy associated with SSc, and a dual endothelin receptor an... |
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The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression.
Cell Commun. Signal. 12 , 76, (2015) Epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 is one of well-recognized factors contributing to renal fibrosis. However, the underlying molecular mechanisms of EMT are not fully understood. Brachyury, an evolutionarily conserved transcription f... |
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5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphé nucleus 5-HT neuronal activity.
J. Physiol. 593 , 2479-97, (2015) We investigated, using single-unit recordings in chloral hydrate-anaesthetized rats, the role of serotonin 4 (5-HT4) receptors in the control of dorsal raphé nucleus (DRN) 5-HT neuron activity. About one-half (36) of the 76 neurons recorded were affected by e... |
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p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling.
Biochim. Biophys. Acta 1852 , 1520-30, (2015) Transforming growth factor-β (TGF-β) induces miR-21 expression which contributes to fibrotic events in the left ventricle (LV) under pressure overload. SMAD effectors of TGF-β signaling interact with DROSHA to promote primary miR-21 processing into precursor ... |
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R-Smad signaling-mediated VEGF expression coordinately regulates endothelial cell differentiation of rat mesenchymal stem cells.
Stem Cells Dev. 24 , 1320-31, (2015) A low-efficiency yield hinders the use of stem cells as a source of endothelial cells (ECs) for therapeutic vascularization, and the diversity of the transforming growth factor-β (TGF-β) superfamily has undermined understanding the effects of its potent vascu... |
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Transforming growth factor-β1 mediates psoriasis-like lesions via a Smad3-dependent mechanism in mice.
Clin. Exp. Pharmacol. Physiol. 41(11) , 921-32, (2014) Transforming growth factor (TGF)-β1 signals through downstream Smad-dependent and -independent pathways to exert its biological actions. It has been reported that overexpression of TGF-β1 results in the development of psoriasis-like lesions in a mouse model o... |
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Transcriptomic analysis of mouse limb tendon cells during development.
Development 141(19) , 3683-96, (2014) The molecular signals driving tendon development are not fully identified. We have undertaken a transcriptome analysis of mouse limb tendon cells that were isolated at different stages of development based on scleraxis (Scx) expression. Microarray comparisons... |
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Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling.
Glia 62(12) , 1917-31, (2014) The balance between excitatory and inhibitory synaptic inputs is critical for the control of brain function. Astrocytes play important role in the development and maintenance of neuronal circuitry. Whereas astrocytes-derived molecules involved in excitatory s... |