2-Butanone,1,4-diamino-, hydrochloride (1:2)
2-Butanone,1,4-diamino-, hydrochloride (1:2) structure
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Common Name | 2-Butanone,1,4-diamino-, hydrochloride (1:2) | ||
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| CAS Number | 3660-09-1 | Molecular Weight | 175.05700 | |
| Density | 1.031g/cm3 | Boiling Point | 223.5ºC at 760mmHg | |
| Molecular Formula | C4H12Cl2N2O | Melting Point | 221ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 89ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A class II histone deacetylase acts on newly synthesized histones in Tetrahymena.
Eukaryotic Cell 7(3) , 471-82, (2008) Newly synthesized histones are acetylated prior to their deposition into nucleosomes. Following nucleosome formation and positioning, they are rapidly deacetylated, an event that coincides with further maturation of the chromatin fiber. The histone deacetylas... |
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1,4-Diamino-2-butanone, a putrescine analogue, promotes redox imbalance in Trypanosoma cruzi and mammalian cells.
Arch. Biochem. Biophys. 528(2) , 103-10, (2012) The putrescine analogue 1,4-diamino-2-butanone (DAB) is highly toxic to various microorganisms, including Trypanosoma cruzi. Similar to other α-aminocarbonyl metabolites, DAB exhibits pro-oxidant properties. DAB undergoes metal-catalyzed oxidation yielding H(... |
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Inhibition of the yeast-mycelial transition and the phorogenesis of Mucorales by diamino butanone.
Arch. Microbiol. 151(1) , 10-4, (1989) Diamino butanone (DAB), a competitive inhibitor of ornithine decarboxylase (ODC) a key enzyme in polyamine biosynthesis, inhibited the yeast to hyphae transition in Mucor rouxii, induced by transfer from anaerobiosis to aerobiosis, but not the opposite phenom... |
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Effects of a putrescine analog on Giardia lamblia.
Parasitol. Res. 103(2) , 363-70, (2008) The protozoan Giardia lamblia is the most frequent intestinal parasite of first-world countries and a major cause of waterborne disorder often referred to as traveler's diarrhea. We have previously noticed that the putrescine analog 1,4-diamino-2-butanone (DA... |
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DNA methylation and polyamines in regulation of development of the fungus Mucor rouxii.
J. Bacteriol. 170(12) , 5946-8, (1988) DNA from intact or spherically growing spores of Mucor rouxii is highly methylated, whereas DNA from germlings has low levels of methylation. DNA from spores incubated with hydroxyurea or 1,4-diaminobutanone is also highly methylated. The reversal of the effe... |
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Correlation between the regulation of sterigmatocystin biosynthesis and asexual and sexual sporulation in Emericella nidulans.
Antonie van Leeuwenhoek 73(2) , 199-205, (1998) We analyzed the regulation of sterigmatocystin biosynthesis in wild type and mutant strains of Emericella nidulans (= Aspergillus nidulans). A positive correlation between both asexual and sexual sporulation and synthesis of the mycotoxin was observed. Those ... |
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Hyphae formation of Candida albicans is regulated by polyamines.
Biol. Pharm. Bull. 27(6) , 890-2, (2004) Candida albicans generally grows in hyphae form in RPMI1640 medium. However, addition of 1,4-diamino-2-butanone (DAB), a competitive inhibitor of ornithine decarboxylase, decreased the amount of polyamines in C. albicans, and induced the proliferation of the ... |
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Sequence, expression and functional analysis of the Coccidioides immitis ODC (ornithine decarboxylase) gene.
Gene 242(1-2) , 437-48, (2000) The ornithine decarboxylase (ODC) gene of the human respiratory fungal pathogen, Coccidioides immitis (Ci) was cloned, sequenced, chromosome-mapped, and expressed in Escherichia coli (Ec). The genomic, cDNA and translated sequences are presented. Transformati... |
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Dependence of protective functions of Escherichia coli polyamines on strength of stress caused by superoxide radicals.
Biochemistry. (Mosc.) 72(1) , 109-16, (2007) Mechanisms of antioxidant effect of polyamines were studied in dependence on the strength of superoxide stress. Under conditions of weak stress, polyamines from Escherichia coli cultures were shown to function mainly as a scavenger of free superoxide radicals... |
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Ornithine decarboxylase in Paracoccidioides brasiliensis.
Arch. Microbiol. 165(5) , 311-6, (1996) Ornithine decarboxylase in Paracoccidioides brasiliensis, a dimorphic human pathogenic fungus, was more active at 37 degrees C in the yeast phase and at 30 degrees C in the mycelial phase. In contrast to other fungal systems, yeast growth and mycelium-to-yeas... |