SKF-96365
SKF-96365 structure
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Common Name | SKF-96365 | ||
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| CAS Number | 130495-35-1 | Molecular Weight | 402.914 | |
| Density | N/A | Boiling Point | 556ºC at 760mmHg | |
| Molecular Formula | C22H27ClN2O3 | Melting Point | 119 °C | |
| MSDS | USA | Flash Point | 290.1ºC | |
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Mechanosensitive Ca²⁺-permeable channels in human leukemic cells: pharmacological and molecular evidence for TRPV2.
Biochim. Biophys. Acta 1848(1 Pt A) , 51-9, (2015) Mechanosensitive channels are present in almost every living cell, yet the evidence for their functional presence in T lymphocytes is absent. In this study, by means of the patch-clamp technique in attached and inside-out modes, we have characterized cationic... |
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STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration.
Biochim. Biophys. Acta 1853(1) , 233-43, (2015) STIM1 is a key regulator of store-operated calcium entry (SOCE), and therefore a mediator of Ca²⁺ entry-dependent cellular events. Phosphorylation of STIM1 at ERK1/2 target sites has been described as enhancing STIM1 activation during intracellular Ca²⁺ empty... |
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ATP releases ATP or other nucleotides from human peripheral blood leukocytes through purinergic P2 receptors.
Life Sci. 145 , 85-92, (2016) Almost every eukaryotic cell releases ATP under certain conditions. The idea that ATP induces the release of ATP has been scantly investigated.We explored this possibility by assessing the rate of exogenous ATP breakdown (measured by phosphates production) by... |
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TRPM8 Channel Activation Induced by Monoterpenoid Rotundifolone Underlies Mesenteric Artery Relaxation.
PLoS ONE 10 , e0143171, (2015) In this study, our aims were to investigate transient receptor potential melastatin-8 channels (TRPM8) involvement in rotundifolone induced relaxation in the mesenteric artery and to increase the understanding of the role of these thermosensitive TRP channels... |
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Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum.
J. Smooth Muscle Res. 41 , 313-327, (2005) In circular smooth muscle bundles isolated from the guinea-pig stomach antrum, the effects of quinidine, Ni2+, flufenamic acid, niflumic acid, La3+, SKF-96365 and 4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS) on acetylcholine (ACh)-induced depolari... |
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STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.
Curr. Biol. 15(13) , 1235-41, (2005) Ca(2+) signaling in nonexcitable cells is typically initiated by receptor-triggered production of inositol-1,4,5-trisphosphate and the release of Ca(2+) from intracellular stores. An elusive signaling process senses the Ca(2+) store depletion and triggers the... |
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SK&F 96365, a novel inhibitor of receptor-mediated calcium entry.
Biochem. J. 271 , 515-522, (1990) A novel inhibitor of receptor-mediated calcium entry (RMCE) is described. SK&F 96365 (1-(beta-[3-(4-methoxy-phenyl)propoxy]-4-methoxyphenethyl)-1H- imidazole hydrochloride) is structurally distinct from the known 'calcium antagonists' and shows selectivity in... |
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Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels.
J. Neurosci. 36 , 3184-98, (2016) The endoplasmic reticulum (ER) is at the epicenter of astrocyte Ca(2+) signaling. We sought to identify the molecular mechanism underlying store-operated calcium entry that replenishes ER stores in mouse Müller cells. Store depletion, induced through blockade... |
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Inhibition of SOCE disrupts cytokinesis in zebrafish embryos via inhibition of cleavage furrow deepening.
Int. J. Dev. Biol. 59 , 289-301, (2015) During the first few cell division cycles in zebrafish, distinct Ca(2+) transients are localized to the early embryonic cleavage furrows, where they accompany (and are required for) furrow positioning, propagation, deepening and apposition. It has previously ... |
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ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species.
Am. J. Physiol. Renal Physiol. 306(9) , F1088-97, (2014) Extracellular ATP may contribute to Ca(2+) signaling in podocytes during tubuloglomerular feedback (TGF) and possibly as a result of local tissue damage. TRPC6 channels are Ca(2+)-permeable cationic channels that have been implicated in the pathophysiology of... |