ccpa
ccpa structure
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Common Name | ccpa | ||
|---|---|---|---|---|
| CAS Number | 37739-05-2 | Molecular Weight | 369.80 | |
| Density | 1.87g/cm3 | Boiling Point | 617.3ºC at 760mmHg | |
| Molecular Formula | C15H20ClN5O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 327.1ºC | |
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Adenosine receptors and muscarinic receptors cooperate in acetylcholine release modulation in the neuromuscular synapse.
Eur. J. Neurosci. 42 , 1775-87, (2015) Adenosine receptors (ARs) are present in the motor terminals at the mouse neuromuscular junction. ARs and the presynaptic muscarinic acetylcholine receptors (mAChRs) share the functional control of the neuromuscular junction. We analysed their mutual interact... |
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Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT.
Clin. Microbiol. Infect. 20(11) , O960-8, (2014) Chronic cavitary pulmonary aspergillosis (CCPA) is an uncommon but serious pulmonary disease of humans, with an annual mortality rate of 10-30%. It is caused by the fungus Aspergillus fumigatus. Patients are overtly immunocompetent; however, some immunogeneti... |
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Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281.
Cell. Signal. 27(5) , 1008-18, (2015) Equilibrative nucleoside transporter subtype 1 (ENT1) is critical for the regulation of the biological activities of endogenous nucleosides such as adenosine, and for the cellular uptake of chemotherapeutic nucleoside analogs. Previous studies have implicated... |
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Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis.
Eur. J. Pharmacol. 650(2-3) , 639-49, (2011) This study investigated the expression of A(1) and A(2A) receptors in the rat colonic neuromuscular compartment, and characterized their roles in the control of motility during inflammation. Colitis was induced by 2,4-dinitrobenzenesulfonic acid. A(1), A(2A) ... |
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Norisoboldine attenuates inflammatory pain via the adenosine A1 receptor.
Eur. J. Pain 18(7) , 939-48, (2014) Norisoboldine (NOR) is a benzylisoquinoline alkaloid isolated from Radix Linderae, a traditional Chinese medicine. Our previous studies have demonstrated that it produces anti-inflammatory and anti-rheumatoid arthritis effects.The present study was undertaken... |
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Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
J. Neurosci. 32(38) , 13100-10, (2012) Astrocytes contribute to many neuronal functions, including synaptogenesis, but their role in the development of synaptic plasticity remains unclear. Presynaptic muting of hippocampal glutamatergic terminals defends against excitotoxicity. Here we studied the... |
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Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study.
Eur. J. Med. Chem. 101 , 185-204, (2015) The 2-amino-3-(p-chlorobenzoyl)thiophene scaffold has been widely employed as a pharmacophore for the identification of small molecules acting as allosteric modulators at the adenosine A1 receptor. A new series of 2-amino-3-(p-chlorobenzoyl)-4-benzyl-5-arylth... |
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Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1 adenosine receptor.
Br. J. Pharmacol. 171(23) , 5295-312, (2014) Many GPCRs can be allosterically modulated by small-molecule ligands. This modulation is best understood in terms of the kinetics of the ligand-receptor interaction. However, many current kinetic assays require at least the (radio)labelling of the orthosteric... |
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Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates.
J. Nanobiotechnology 6 , 12, (2008) An approach to use multivalent dendrimer carriers for delivery of nucleoside signaling molecules to their cell surface G protein-coupled receptors (GPCRs) was recently introduced.A known adenosine receptor (AR) agonist was conjugated to polyamidoamine (PAMAM)... |
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Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors.
Neuropharmacology 93 , 103-15, (2015) This study assessed the anticonvulsant and seizure generation effects of carbamazepine (CBZ), oxcarbazepine (OXC) and eslicarbazepine (S-Lic) in wild-type mice. Electrophysiological recordings were made to discriminate potential cellular and synaptic mechanis... |