SNC80
SNC80 structure
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Common Name | SNC80 | ||
|---|---|---|---|---|
| CAS Number | 156727-74-1 | Molecular Weight | 449.628 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 564.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C28H39N3O2 | Melting Point | 122-123ºC | |
| MSDS | Chinese USA | Flash Point | 295.4±30.1 °C | |
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PKA and ERK1/2 are involved in dopamine D₁ receptor-induced heterologous desensitization of the δ opioid receptor.
Life Sci. 92(23) , 1101-9, (2013) Chronic administration of cocaine attenuates delta opioid receptor (DOPR) signaling in the striatum and the desensitization is mediated by the indirect actions of cocaine on dopamine D1 receptors (D1R). In addition, DOPR and D1R co-exist in some rat striatal ... |
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Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling.
J. Pharmacol. Exp. Ther. 344(1) , 179-88, (2013) Drugs targeting G-protein-coupled receptors (GPCRs) make up more than 25% of all prescribed medicines. The ability of GPCRs to form heteromers with unique signaling properties suggests an entirely new and unexplored pool of drug targets. However, current in v... |
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Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety.
J. Pharmacol. Exp. Ther. 335(1) , 133-9, (2010) Alcoholism and anxiety disorders have a huge impact on society and afflict 17.6 million and 40 million people in the United States, respectively. A strong comorbidity exists between alcoholism and anxiety disorders. Indeed, alcohol withdrawal-induced anxiety ... |
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Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.
Pain 148(1) , 84-93, (2010) Transcutaneous electrical nerve stimulation (TENS) is a treatment for pain that involves placement of electrical stimulation through the skin for pain relief. Previous work from our laboratory shows that repeated application of TENS produces analgesic toleran... |
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Effects of the delta-opioid agonist SNC80 on the abuse liability of methadone in rhesus monkeys: a behavioral economic analysis.
Psychopharmacology 216(3) , 431-9, (2011) Delta-opioid agonists enhance the antinociceptive efficacy of methadone and other mu-opioid agonists. However, relatively little is known about the degree to which delta agonists might enhance the abuse-related effects of mu agonists.This study used a behavio... |
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Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration.
Bioorg. Med. Chem. Lett. 20(21) , 6302-5, (2010) We have reported previously the novel δ-opioid agonist, SN-28, which was more potent in in vitro assays than the prototype δ-agonists, TAN-67 and SNC-80. However, when administered by subcutaneous injection, this compound showed no analgesic effect at dosages... |
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Modulation of μ-opioid receptor signaling by RGS19 in SH-SY5Y cells.
Mol. Pharmacol. 83(2) , 512-20, (2013) Regulator of G-protein signaling protein 19 (RGS19), also known as Gα-interacting protein (GAIP), acts as a GTPase accelerating protein for Gαz as well as Gαi/o subunits. Interactions with GAIP-interacting protein N-terminus and GAIP-interacting protein C-ter... |
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Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists.
Drug Alcohol Depend. 122(1-2) , 156-9, (2012) Naltrexone is one of the few drugs approved by the Federal Drug Administration for the treatment of alcoholism. However, naltrexone is only effective in a subpopulation of treatment-seeking alcohol abusers, and suffers from compliance issues. The non-selectiv... |
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Involvement of the kappa-opioid receptor in nitrous oxide-induced analgesia in mice.
J. Anesth. 24(2) , 297-9, (2010) Nitrous oxide (N(2)O)-induced analgesia is thought to be mediated by endogenous opioids. We previously showed that the mu-opioid receptor is not required for the analgesic action of N(2)O in mice using a gene knockout approach. In this study, we examined the ... |
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Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels.
Mol. Pain 9 , 8, (2013) Opioid receptors regulate a diverse array of physiological functions. Mu opioid receptor agonists are well-known analgesics for treating acute pain. In contrast, animal models suggest that chronic pain is more effectively relieved by delta opioid receptor ago... |