N1-Cyclohexylpropane-1,3-diamine
N1-Cyclohexylpropane-1,3-diamine structure
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Common Name | N1-Cyclohexylpropane-1,3-diamine | ||
|---|---|---|---|---|
| CAS Number | 3312-60-5 | Molecular Weight | 156.268 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 238.7±8.0 °C at 760 mmHg | |
| Molecular Formula | C9H20N2 | Melting Point | −17-−15 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 112.3±22.0 °C | |
| Symbol |
GHS05 |
Signal Word | Danger | |
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Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues.
Biochem. Pharmacol. 45(9) , 1897-903, (1993) Several inhibitors of aminopropyltransferases, developed recently in this laboratory, were tested for their specificity by measuring their effects on six enzyme activities related to polyamine biosynthesis and interconversion. Two of them, trans-4-methylcyclo... |
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Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.
J. Biochem. 117(2) , 339-45, (1995) The effects of a potent spermidine synthase inhibitor, trans-4-methylcyclohexylamine (4MCHA), and a spermine synthase inhibitor, N-(3-aminopropyl)cyclohexylamine (APCHA), on polyamine biosynthesis and cell growth have been studied in rat hepatoma cells (HTC c... |
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Inhibition of cell growth by combination of alpha-difluoromethylornithine and an inhibitor of spermine synthase.
J. Biochem. 117(4) , 824-9, (1995) The inhibitory effect on cell growth of a combination of alpha-difluoromethylornithine (DFMO) and an inhibitor of aminopropyl transferase was examined. N-(3-aminopropyl)cyclohexylamine (APCHA) and trans-4-methylcyclohexylamine (4MCHA) were used as inhibitors ... |
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Spermidine regulates insulin synthesis and cytoplasmic Ca(2+) in mouse beta-TC6 insulinoma cells.
Cell Struct. Funct. 34(2) , 105-13, (2009) In order to assess the functional role of the polyamines spermidine and spermine in pancreatic beta-cells, we examined the effect of spermidine and spermine synthase inhibitors, trans-4-methylcyclohexylamine (MCHA) and N-(3-aminopropyl)cyclohexylamine (APCHA)... |
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N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo.
Eur. J. Pharmacol. 256(2) , 155-60, (1994) The facilitating or antagonizing effects of polyamine analogues on N-methyl-DL-aspartate (NMDLA)-induced seizures were investigated using mice. Intracerebroventricular injection of spermidine and spermine, but not putrescine, shortened the latency to appearan... |
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Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells.
Cancer Res. 55(4) , 934-43, (1995) Spermine is often the most abundant polyamine in human tumors such as breast carcinomas. However, its specific role in tumor biology is still uncertain, since inhibitors of ornithine decarboxylase such as alpha-difluoromethylornithine depress cell growth whil... |
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Independent roles of eIF5A and polyamines in cell proliferation.
Biochem. J. 385(Pt 3) , 779-85, (2005) To examine the roles of active hypusinated eIF5A (eukaryotic translation initiation factor 5A) and polyamines in cell proliferation, mouse mammary carcinoma FM3A cells were treated with an inhibitor of deoxyhypusine synthase, GC7 (N1-guanyl-1, 7-diaminoheptan... |
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Preparation, characterization and in vitro anticancer activity of platinum(II) complexes with N-Cyclohexyl-1,3-propanediamine as the carrier.
Chem. Pharm. Bull. 56(5) , 659-62, (2008) New JM118 (active form of satraplatin) analogues with N-cyclohexyl-1,3-propanediamine (N-chpda) as the carrier, cis-[Pt(N-chpda)X2] (X2=2Cl(-) (1), oxalate (2), malonate (3), 1,1-cyclobutanedicarboxylate (CBDCA) (3), and 3-hydroxy-1,1-cyclobutanedicarboxylate... |