ODQ
ODQ structure
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Common Name | ODQ | ||
|---|---|---|---|---|
| CAS Number | 41443-28-1 | Molecular Weight | 187.155 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 321.3±25.0 °C at 760 mmHg | |
| Molecular Formula | C9H5N3O2 | Melting Point | 160-170 °C | |
| MSDS | Chinese USA | Flash Point | 148.1±23.2 °C | |
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Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation.
BMC Cancer 15 , 17, (2015) DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in anticancer responses; in this regard, combination therapies ab... |
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Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension.
PLoS ONE 10 , e0134876, (2015) Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-contracted with KCl or carbachol (CCh), and the phosphorylat... |
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Isosorbide dinitrate inhibits mechanical stress-induced cardiac hypertrophy and autophagy through downregulation of angiotensin II type 1 receptor.
J. Cardiovasc. Pharmacol. 65(1) , 1-7, (2015) Mechanical stress can induce cardiac hypertrophy and autophagy. Recently, it has been reported that nitric oxide donors inhibited autophagy in human chondrocytes. Therefore, the effect of isosorbide dinitrate (ISDN) on cardiac hypertrophy and autophagy induce... |
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Vasorelaxant effects of 1-nitro-2-phenylethene in rat isolated aortic rings.
Vascul. Pharmacol. 63(2) , 55-62, (2014) Previously, we showed that nitro-2-phenylethane is a vasorelaxant constituent of the essential oil of Aniba canelilla. Here, we investigated the mechanisms underlying the vascular effects of 1-nitro-2-phenylethene (NPe), a structural analog of 1-nitro-2-pheny... |
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Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP.
Thromb. Res. 134(6) , 1301-10, (2014) CME-1, a novel water-soluble polysaccharide, was purified from the mycelia of Cordyceps sinensis, and its chemical structure was characterized to contain mannose and galactose in a ratio of 4:6 (27.6 kDa). CME-1 was originally observed to exert a potent inhib... |
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A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
Sci. Signal. 8 , ra71, (2015) Loss of NOTCH signaling in postnatal murine joints results in osteoarthritis, indicating a requirement for NOTCH during maintenance of joint cartilage. However, NOTCH signaling components are substantially increased in abundance in posttraumatic osteoarthriti... |
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Carbon monoxide (CO) is a novel inhibitor of connexin hemichannels.
J. Biol. Chem. 289(52) , 36150-7, (2014) Hemichannels (HCs) are hexamers of connexins that can form gap-junction channels at points of cell contacts or "free HCs" at non-contacting regions. HCs are involved in paracrine and autocrine cell signaling, and under pathological conditions may induce and/o... |
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Effects of dynamic shear and transmural pressure on wall shear stress sensitivity in collecting lymphatic vessels.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 309 , R1122-34, (2015) Given the known mechanosensitivity of the lymphatic vasculature, we sought to investigate the effects of dynamic wall shear stress (WSS) on collecting lymphatic vessels while controlling for transmural pressure. Using a previously developed ex vivo lymphatic ... |
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The Nitric oxide/CGMP/KATP pathway mediates systemic and central antinociception induced by resistance exercise in rats.
Int. J. Neurosci. 125 , 765-73, (2015) Resistance exercise (RE) is characterized to increase strength, tone, mass, and/or muscular endurance and also for produces many beneficial effects, such as blood pressure and osteoporosis reduction, diabetes mellitus control, and analgesia. However, few stud... |
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Reduced vascular responses to soluble guanylyl cyclase but increased sensitivity to sildenafil in female rats with type 2 diabetes.
Am. J. Physiol. Heart Circ. Physiol. 309 , H297-304, (2015) Impaired nitric oxide (NO), soluble guanylyl cyclase (sGC), and cyclic guanosine monophosphate (cGMP) signaling (NO-sGC-cGMP) has been implicated in the pathogenesis of diabetic vascular dysfunction. Efforts to directly target this signaling have led to the d... |