1-(4-Fluorophenyl)piperazine
1-(4-Fluorophenyl)piperazine structure
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Common Name | 1-(4-Fluorophenyl)piperazine | ||
|---|---|---|---|---|
| CAS Number | 2252-63-3 | Molecular Weight | 180.22200 | |
| Density | 1.0 | Boiling Point | 118-123 °C0.1 mm Hg(lit.) | |
| Molecular Formula | C10H13FN2 | Melting Point | 30-33 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | >230 °F | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder.
J. Psychiatr. Res. 43(10) , 887-94, (2009) Serotonin-1A receptors may play a role in the pathophysiology of depression and suicide. In postmortem brain tissue, agonist binding to serotonin-1A receptors is reportedly increased or unchanged in depression or suicide, while neuroimaging studies report a d... |
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The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain.
Neuropharmacology 21(2) , 163-9, (1982) Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-HT) levels were unchanged. Niaprazine also produced a short... |
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Rapid synthesis of N, N'-disubstituted piperazines. Application to the preparation of No carrier added 1-(4-[18F] fluorophenyl) piperazine and of an [18F]-selective ligand of serotoninergic receptors (5HT2 antagonist). Collins M, et al.
J. Chem. Soc. Perkin Trans. I 23 , 3185-88, (1992)
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