N-iodosuccinimide
N-iodosuccinimide structure
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Common Name | N-iodosuccinimide | ||
|---|---|---|---|---|
| CAS Number | 516-12-1 | Molecular Weight | 224.984 | |
| Density | 2.3±0.1 g/cm3 | Boiling Point | 249.6±23.0 °C at 760 mmHg | |
| Molecular Formula | C4H4INO2 | Melting Point | 202-206 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 104.8±22.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Phenotype and function of nasal dendritic cells.
Mucosal Immunol. 8 , 1083-98, (2015) Intranasal (i.n.) vaccination generates immunity across local, regional, and distant sites. However, nasal dendritic cells (DCs), pivotal for the induction of i.n. vaccine-induced immune responses, have not been studied in detail. Here, by using a variety of ... |
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Reduced parasite motility and micronemal protein secretion by a p38 MAPK inhibitor leads to a severe impairment of cell invasion by the apicomplexan parasite Eimeria tenella.
PLoS ONE 10(2) , e0116509, (2015) E. tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to infection and are divided in three pathways: p38, extracellu... |
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Differential expression of CART in feeding and reward circuits in binge eating rat model.
Behav. Brain Res. 291 , 219-31, (2015) Binge eating (BE) disrupts feeding and subverts reward mechanism. Since cocaine- and amphetamine-regulated transcript peptide (CART) mediates satiety as well as reward, its role in BE justifies investigation. To induce BE, rats were provided restricted access... |
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Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species.
Endocrinology 156(4) , 1540-51, (2015) Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the intracellular conc... |
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ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
J. Cell Biol. 211 , 339-58, (2015) Invasion of cancer cells into collagen-rich extracellular matrix requires membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) as the key protease for collagen breakdown. Understanding how MT1-MMP is delivered to the surface of tumor cells is ... |
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Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3.
Mol. Oncol. 9 , 818-33, (2015) Deregulated activation of oncogenic transcription factors such as signal transducer and activator of transcription 3 (STAT3) plays a pivotal role in proliferation and survival of hepatocellular carcinoma (HCC). Thus, agents which can inhibit STAT3 activation ... |
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Testosterone and estradiol treatments differently affect pituitary-thyroid axis and liver deiodinase 1 activity in orchidectomized middle-aged rats.
Exp. Gerontol. 72 , 85-98, (2015) We previously reported that orchidectomy (Orx) of middle-aged rats (15-16-month-old; MA) slightly affected pituitary-thyroid axis, but decreased liver deiodinase (Dio) type 1 and pituitary Dio2 enzyme activities. At present, we examined the effects of subsequ... |
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Cardiac AAV9 Gene Delivery Strategies in Adult Canines: Assessment by Long-term Serial SPECT Imaging of Sodium Iodide Symporter Expression.
Mol. Ther. 23 , 1211-21, (2015) Heart failure is a leading cause of morbidity and mortality, and cardiac gene delivery has the potential to provide novel therapeutic approaches. Adeno-associated virus serotype 9 (AAV9) transduces the rodent heart efficiently, but cardiotropism, immune toler... |
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Three-component access to pyrroles promoted by the CAN-silver nitrate system under high-speed vibration milling conditions: a generalization of the Hantzsch pyrrole synthesis.
Chem. Commun. (Camb.) 49(6) , 591-3, (2013) A sequential multicomponent process involving the high-speed vibration milling of ketones with N-iodosuccinimide and p-toluenesulfonic acid, followed by addition of a mixture of primary amines, β-dicarbonyl compounds, cerium(IV) ammonium nitrate and silver ni... |
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In Vitro, Ex Vivo, and In Vivo Determination of Thyroid Hormone Modulating Activity of Benzothiazoles.
Toxicol. Sci. 146 , 254-64, (2015) As in vitro assays are increasingly used to screen chemicals for their potential to produce endocrine disrupting adverse effects, it is important to understand their predictive capacity. The potential for a set of 6 benzothiazoles to affect endpoints related ... |