Dexmedetomidine hydrochloride
Dexmedetomidine hydrochloride structure
|
Common Name | Dexmedetomidine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 145108-58-3 | Molecular Weight | 236.740 | |
| Density | N/A | Boiling Point | 381.9ºC at 760 mmHg | |
| Molecular Formula | C13H17ClN2 | Melting Point | 153 - 158ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Effect of corneal contact lens wear on healing time and comfort post LGK for treatment of SCCEDs in boxers.
Vet. Ophthalmol. 18 , 364-70, (2015) To determine whether dogs with spontaneous chronic corneal epithelial defects (SCCEDs) would heal faster and with an improved comfort score following linear grid keratotomy (LGK) combined with corneal contact lens (Acrivet(™) ) wear when compared to dogs havi... |
|
|
Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons.
Mol. Psychiatry 19(7) , 823-33, (2014) 3,4-Methylenedioxymethamphetamine (MDMA or 'ecstasy') is a psychostimulant drug, widely used recreationally among young people in Europe and North America. Although its neurotoxicity has been extensively described, little is known about its ability to strengt... |
|
|
Optimized on-line enantioselective capillary electrophoretic method for kinetic and inhibition studies of drug metabolism mediated by cytochrome P450 enzymes.
Electrophoresis 36 , 1349-57, (2015) Pharmacokinetic and pharmacodynamic properties of a chiral drug can significantly differ between application of the racemate and single enantiomers. During drug development, the characteristics of candidate compounds have to be assessed prior to clinical test... |
|
|
Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine in the horse.
J. Vet. Pharmacol. Ther. 38(1) , 15-23, (2015) The aim of the study was to describe the pharmacokinetics and selected pharmacodynamics of intravenous dexmedetomidine in horses. Eight adult horses received 5 μg/kg dexmedetomidine IV. Blood samples were collected before and for 10 h after drug administratio... |
|
|
The effects of taurine on vigabatrin, high light intensity and mydriasis induced retinal toxicity in the pigmented rat.
Exp. Toxicol. Pathol. 67(1) , 13-20, (2014) The overall purpose of this study was to establish a model that may be used for examining the effect of Vigabatrin-induced retinal toxicity in pigmented rats, and subsequently examine the possible effects of taurine on the retinal toxicity. In the first part ... |
|
|
Effect of an extruded pea or rice diet on postprandial insulin and cardiovascular responses in dogs.
J. Anim. Physiol. Anim. Nutr. (Berl.) 99 , 767-76, (2015) Peas are increasing in popularity as a source of carbohydrate, protein and fibre in extruded canine diets. The aim of this study was to test the health effects of two canine diets with identical macronutrient profiles, but containing either yellow field peas ... |
|
|
Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects.
Eur. J. Clin. Pharmacol. 71 , 1197-207, (2015) Dexmedetomidine is an α2-adrenoceptor agonist used for perioperative and intensive care sedation. This study develops mechanism-based population pharmacokinetic-pharmacodynamic models for the cardiovascular and central nervous system (CNS) effects of intraven... |
|
|
Dexmedetomidine pharmacokinetics in the obese.
Eur. J. Clin. Pharmacol. 71 , 1501-8, (2015) This study aims to characterize the influence of body weight and composition on the pharmacokinetics of dexmedetomidine.Twenty obese patients and 20 non-obese patients scheduled for elective laparoscopic surgery were given dexmedetomidine infusion schemes. Ve... |
|
|
Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine.
Invest. Ophthalmol. Vis. Sci. 56 , 3820-6, (2015) Amino-amide or amino-ester local anesthetics, which are currently used for topical ocular anesthesia, are short acting and may delay corneal healing with long-term use. In contrast, site 1 sodium channel blockers (S1SCBs) are potent local anesthetics with min... |
|
|
Trained vs untrained evaluator assessment of body condition score as a predictor of percent body fat in adult cats.
J. Feline Med. Surg. 16(12) , 957-65, (2014) Body condition scoring (BCS) provides a readily available technique that can be used by both veterinary professionals and owners to assess the body condition of cats, and diagnose overweight or underweight conditions. The objective of this study was to evalua... |